Can thermostable vaccines help address cold-chain challenges? Results from stakeholder interviews in six low- and middle-income countries

Vaccine
Debra KristensenShirley Villadiego

Abstract

This study captures the perspectives of stakeholders at multiple levels of the vaccine supply chain regarding their assessment of challenges with storing vaccines within recommended temperature ranges and their perceptions on the benefits of having vaccines with improved stability, including the potential short-term storage and transport of vaccines in a controlled-temperature chain. Semi-structured interviews were undertaken with 158 immunization stakeholders in six countries. Interviewees included national decision-makers and advisors involved in vaccine purchasing decisions, national Expanded Programme on Immunization managers, and health and logistics personnel at national, subnational, and health facility levels. Challenges with both heat and freeze-exposure of vaccines were recognized in all countries, with heat-exposure being a greater concern. Conditions leading to freeze-exposure including ice build-up due to poor refrigerator performance and improper icepack conditioning were reported by 53% and 28% of participants, respectively. Respondents were interested in vaccine products with improved heat/freeze-stability characteristics. The majority of those involved in vaccine purchasing indicated they would be willing to pa...Continue Reading

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Citations

Sep 20, 2016·Enfermería clínica·Israel Larena FernándezMaría Jesús Blasco Pérez-Aramendía
Mar 19, 2019·Human Vaccines & Immunotherapeutics·Nitesh K KundaPavan Muttil
Jul 17, 2020·Nature Nanotechnology·Matthew D ShinNicole F Steinmetz
Dec 8, 2017·Porcine Health Management·Frédéric Vangroenweghe
Oct 13, 2017·International Journal of Pharmaceutics·Stephanie LongetEd C Lavelle
Feb 1, 2019·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Carly Fleagle ChisholmTheodore W Randolph
Mar 17, 2021·Expert Review of Vaccines·Yizhi Qi, Christopher B Fox
Apr 12, 2021·Vaccine·Sonia PagliusiStephen Jarrett
Oct 31, 2018·Molecular Pharmaceutics·José Vicente González-AramundizNoemi Stefánia Csaba

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