Can transcranial direct current stimulation enhance outcomes from cognitive training? A randomized controlled trial in healthy participants

The International Journal of Neuropsychopharmacology
Donel MartinColleen K Loo

Abstract

Computer-administered cognitive training (CT) tasks are a common component of cognitive remediation treatments. There is growing evidence that transcranial direct current stimulation (tDCS), when given during cognitive tasks, improves performance. This randomized, controlled trial explored the potential synergistic effects of CT combined with tDCS in healthy participants. Altogether, 60 healthy participants were randomized to receive either active or sham tDCS administered during training on an adaptive CT task (dual n-back task), or tDCS alone, over 10 daily sessions. Cognitive testing (working memory, processing speed, executive function, reaction time) was conducted at baseline, end of the 10 sessions, and at 4-wk follow-up to examine potential transfer effects to non-trained tasks. Altogether, 54 participants completed the study. Over the 10 'online' sessions, participants in the active tDCS+CT condition performed more accurately on the CT task than participants who received sham tDCS+CT. The performance enhancing effect, however, was present only during tDCS and did not result in greater learning (i.e. improvement over sessions) on the CT task. These results confirm prior reports of enhancement of cognitive function during...Continue Reading

References

Nov 9, 2002·Journal of Clinical and Experimental Neuropsychology·Torkel KlingbergHelena Westerberg
Dec 31, 2003·Nature Neuroscience·Pernille J OlesenTorkel Klingberg
Feb 4, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·Torkel KlingbergHelena Westerberg
Jul 7, 2005·Experimental Brain Research·Felipe FregniAlvaro Pascual-Leone
Apr 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Susanne M JaeggiWalter J Perrig
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Janine ReisJohn W Krakauer
Feb 10, 2009·Journal of Affective Disorders·Abraham P Arul-Anandam, Colleen Loo
Aug 13, 2009·The International Journal of Neuropsychopharmacology·Colleen K LooPhilip Mitchell
Jun 18, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Vera MoliadzeWalter Paulus
Jan 15, 2011·Stroke; a Journal of Cerebral Circulation·Julius FridrikssonChris Rorden
Apr 15, 2011·Nature·Douglas Fox
Jun 21, 2011·Neurobiology of Aging·Agnes FlöelStefan Knecht
Jan 5, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Colleen K LooPerminder Sachdev
Apr 26, 2012·Experimental Brain Research·Thomas DityeMichal Lavidor
Jun 20, 2012·Journal of Experimental Psychology. General·Thomas S RedickRandall W Engle
Nov 14, 2012·Journal of Affective Disorders·Donel M MartinColleen K Loo

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Citations

May 9, 2014·Neurobiology of Learning and Memory·Fioravante CaponeVincenzo Di Lazzaro
Dec 3, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marie-Anne VanderhasseltAndre R Brunoni
Sep 6, 2014·Trends in Neurosciences·Hannah L FilmerJason B Mattingley
Dec 10, 2015·Journal of Clinical and Experimental Neuropsychology·Brenda W V van WesselJos N van der Geest
Dec 17, 2015·Bipolar Disorders·Donel M MartinColleen K Loo
Dec 24, 2015·Frontiers in Aging Neuroscience·Jonna NilssonMartin Lövdén
Dec 15, 2015·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·David MuehsamBlake T Gurfein
Aug 31, 2013·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Marcus MeinzerAgnes Flöel
Apr 8, 2016·Journal of Cognitive Neuroscience·Lauren E MancusoMartha J Farah
Sep 2, 2015·Journal of Clinical and Experimental Neuropsychology·Kathy S ChiouNancy D Chiaravalloti
Jan 28, 2015·Restorative Neurology and Neuroscience·Jessica ElmasryDonel Martin
Apr 19, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Margaret KasschauLeigh E Charvet
Dec 31, 2014·Brain Stimulation·Aparna Menon Tarur PadinjareveettilDonel Martin
May 12, 2016·Journal of Cognitive Neuroscience·Jacky AuJohn Jonides
Jul 5, 2016·Frontiers in Human Neuroscience·Tjeerd W BoonstraColleen K Loo
Jun 18, 2016·Journal of Cognitive Neuroscience·Joni HolmesMichael P Ewbank
Oct 30, 2016·Drug and Alcohol Dependence·James LougheadCaryn Lerman
Mar 3, 2017·Journal of Cognitive Neuroscience·Benjamin KatzJohn Jonides
Feb 13, 2018·Journal of Clinical and Experimental Neuropsychology·Roanne Hurley, Liana Machado
Oct 16, 2018·Journal of Clinical and Experimental Neuropsychology·Naomi WhiteLiana Machado
Feb 21, 2014·F1000Research·Níall LallyJonathan P Roiser

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