Can transient elastography replace liver histology for determination of advanced fibrosis in alcoholic patients: a real-life study

Journal of Clinical Gastroenterology
Filip JanssensPeter Stärkel

Abstract

Consensus is lacking whether cut-off values for different fibrosis stages using transient elastography (TE, FibroScan) are universally applicable to all liver diseases. We evaluated the performance of TE in predicting severe fibrosis (> or =F3) in alcoholic patients using cut-off values validated for chronic hepatitis C. Patients admitted for alcohol withdrawal were prospectively evaluated by TE and biochemistry for aspartate aminotransferase to platelet ratio index (APRI) and Forns score calculations. If TE revealed severe fibrosis (> or =F3), hepatic venous pressure gradient measurements and transjugular liver biopsy were proposed results of which were correlated and compared with TE measurements or APRI and Forns scores. Among 239 patients, 72 had liver TE scores > or =F3 and 23 declined liver biopsy leaving a final study population of 49 patients. Compared with biopsy, 32 patients were correctly classified by TE, whereas 16 patients differed by 2 fibrosis stages yielding a positive predictive value of 65% for liver fibrosis > or =F3 at TE. Specificity and sensitivity of TE improved beyond 75% and 70%, respectively, with modified cut-offs of 17 (F3) and 21.1 kPa (F4). Areas under the receiver operating characteristic curves ...Continue Reading

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Citations

Sep 26, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Praveen Sharma, Ashish Kumar
Jan 23, 2015·The Cochrane Database of Systematic Reviews·Chavdar S PavlovChristian Gluud
Nov 12, 2016·Open Forum Infectious Diseases·Leire Pérez-LatorreJuan Berenguer
Oct 31, 2014·World Journal of Gastroenterology : WJG·Sebastian MuellerVanessa Rausch
Oct 27, 2015·World Journal of Gastroenterology : WJG·Rosa LombardiEmmanuel A Tsochatzis
Nov 18, 2015·World Journal of Gastroenterology : WJG·Monica Lupsor-Platon, Radu Badea
Sep 13, 2020·Abdominal Radiology·Cheng Fang, Paul S Sidhu
Apr 9, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Jean Louis FrossardLaurent Spahr
Aug 15, 2018·Journal of Clinical Gastroenterology·Melissa SalavrakosPeter Stärkel
Mar 14, 2020·Health Science Reports·Alia HadefiChristophe Moreno
Mar 24, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jin-Yong JoungChang-Gue Son
Jun 3, 2021·International Journal of Molecular Sciences·Szu-Yi LiuYin-Chou Hsu
May 21, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Rochelle SylvesterNick Sheron
Jun 25, 2021·World Journal of Gastroenterology : WJG·Daniel FusterRobert Muga

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