Can Untargeted Metabolomics Be Utilized in Drug Discovery/Development?

Current Topics in Medicinal Chemistry
Gary W Caldwell, Gregory C Leo

Abstract

Untargeted metabolomics is a promising approach for reducing the significant attrition rate for discovering and developing drugs in the pharmaceutical industry. This review aims to highlight the practical decision-making value of untargeted metabolomics for the advancement of drug candidates in drug discovery/development including potentially identifying and validating novel therapeutic targets, creating alternative screening paradigms, facilitating the selection of specific and translational metabolite biomarkers, identifying metabolite signatures for the drug efficacy mechanism of action, and understanding potential drug-induced toxicity. The review provides an overview of the pharmaceutical process workflow to discover and develop new small molecule drugs followed by the metabolomics process workflow that is involved in conducting metabolomics studies. The pros and cons of the major components of the pharmaceutical and metabolomics workflows are reviewed and discussed. Finally, selected untargeted metabolomics literature examples, from primarily 2010 to 2016, are used to illustrate why, how, and where untargeted metabolomics can be integrated into the drug discovery/preclinical drug development process.

Citations

Aug 30, 2020·Analytical and Bioanalytical Chemistry·Sergey OsipenkoYury Kostyukevich
Dec 12, 2018·PloS One·Henrik Antti, Magnus Sellstedt
Nov 26, 2020·Chinese Medical Journal·Ni LianMin Chen

Related Concepts

Metabolomics
Drug Prospecting
Biological Markers
Drug Industry
Pharmaceutical Preparations
Literature
Protein Biosynthesis
Toxic Effect
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Metabolite

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