Can We Improve Vaccine Efficacy by Targeting T and B Cell Repertoire Convergence?

Frontiers in Immunology
Katja Fink

Abstract

Traditional vaccine development builds on the assumption that healthy individuals have virtually unlimited antigen recognition repertoires of receptors in B cells and T cells [the B cell receptor (BCR) and TCR respectively]. However, there are indications that there are "holes" in the breadth of repertoire diversity, where no or few B or T cell are able to bind to a given antigen. Repertoire diversity may in these cases be a limiting factor for vaccine efficacy. Assuming that it is possible to predict which B and T cell receptors will respond to a given immunogen, vaccine strategies could be optimized and personalized. In addition, vaccine testing could be simplified if we could predict responses through sequencing BCR and TCRs. Bulk sequencing has shown putatively specific converging sequences after infection or vaccination. However, only single cell technologies have made it possible to capture the sequence of both heavy and light chains of a BCR or the alpha and beta chains the TCR. This has enabled the cloning of receptors and the functional validation of a predicted specificity. This review summarizes recent evidence of converging sequences in infectious diseases. Current and potential future applications of single cell te...Continue Reading

References

Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Venkatasamy ManivelKanury V S Rao
Feb 28, 2008·Nature Reviews. Immunology·Vanessa VenturiMiles P Davenport
May 3, 2008·Immunity·Laurent MalherbeMichael G McHeyzer-Williams
Oct 14, 2008·Expert Opinion on Biological Therapy·Gregory A PolandRobert M Jacobson
Mar 9, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vanessa VenturiDaniel C Douek
May 18, 2012·Science Translational Medicine·David WuHarlan Robins
Oct 12, 2012·Bioinformatics·Ryan BrenkeDima Kozakov
Nov 16, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Meihui XuKatja Fink
Apr 5, 2013·Nature·Hua-Xin LiaoBarton F Haynes
Jun 19, 2013·Cell Host & Microbe·Poornima ParameswaranAndrew Z Fire
Jan 5, 2014·Nature Protocols·Simone PicelliRickard Sandberg
Jan 21, 2014·Nature Biotechnology·George GeorgiouStephen R Quake
Mar 19, 2014·Frontiers in Immunology·Daniela Weiskopf, Alessandro Sette
Mar 29, 2014·Proteins·Juan C AlmagroGary L Gilliland
Feb 6, 2015·Journal of Virology·William S DeWittHarlan S Robins
Jul 22, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Uri Hershberg, Eline T Luning Prak
Sep 16, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S D MartinB H Nelson
Nov 22, 2015·Genome Medicine·Gur Yaari, Steven H Kleinstein
Dec 4, 2015·Science Translational Medicine·Sarah F AndrewsPatrick C Wilson
Mar 8, 2016·Nature Methods·Michael J T StubbingtonSarah A Teichmann
Apr 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Brandon J DeKoskyGeorge Georgiou
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Olga V BritanovaDmitriy M Chudakov
Dec 28, 2016·Genomics, Proteomics & Bioinformatics·Yin TongJiankui He
Feb 24, 2017·Computational and Structural Biotechnology Journal·C Marks, C M Deane
Mar 28, 2017·Trends in Biotechnology·Simon FriedensohnSai T Reddy
May 12, 2017·Current Opinion in Biotechnology·Michael T Bethune, Alok V Joglekar
Jun 22, 2017·Nature·Jacob GlanvilleMark M Davis
Aug 5, 2017·Vaccine·G A PolandR B Kennedy
Sep 21, 2017·Journal of Leukocyte Biology·Thi H O NguyenKatherine Kedzierska
Oct 5, 2017·Nucleic Acids Research·Mikhail ShugayDmitriy M Chudakov

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Citations

Sep 27, 2019·Frontiers in Immunology·Theinmozhi ArulrajMichael Meyer-Hermann
Nov 13, 2020·Frontiers in Immunology·Branca PereiraArne N Akbar
Feb 21, 2021·Seminars in Immunopathology·David GranadierJarrod A Dudakov
May 26, 2021·Human Vaccines & Immunotherapeutics·Mark VerdeciaFouad Atouf
Jun 29, 2021·Frontiers in Immunology·Thomas Peacock, Benny Chain

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Methods Mentioned

BETA
transfection
blood draws
interaction prediction
phage display
RNAseq
single cell sequencing

Software Mentioned

seq2
SnugDock
Smart
ClusPro
10xGenomic

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