Can we predict early recurrence in acute stroke?

Cerebrovascular Diseases
Enrique C LeiraHarold P Adams

Abstract

The prevention of early recurrent stroke, which worsens outcomes after a cerebral infarction, is a major objective for acute stroke therapy. The ability to predict which patients are at risk for early recurrence would be useful for both the management and design of clinical trials. Using the prospective database with the 1,266 stroke patients admitted in the TOAST study, we analyzed all the patients who had suffered either a transient ischemic attack (TIA) or a recurrent stroke within 3 months after stroke, and their possible association with 20 selected clinical variables. Both univariate and stepwise regression analyses were performed. Sixty-two patients (4.9%) had a second stroke, and 47 patients (3.7%) had at least one TIA. No particular high-risk period was observed. Early recurrent stroke was associated with the large artery atherosclerosis subtype. A prior history of TIA increased the odds for recurrent stroke (OR = 2.52; 1.16-5.46) or poststroke TIA (OR = 3.46; 1.59-7.48). In addition, patients who had a TIA after the stroke had a 17% chance of having an early recurrent stroke, as compared with 4.4% among those that did not (p = 0.001). Our present ability to identify patients at risk for early recurrence based on basel...Continue Reading

References

Jul 1, 1992·Stroke; a Journal of Cerebral Circulation·L B Goldstein, A Perry
Aug 1, 1989·Stroke; a Journal of Cerebral Circulation·R L SaccoT R Price
Jan 1, 1987·Stroke; a Journal of Cerebral Circulation·P B Gorelick
Sep 1, 1983·Stroke; a Journal of Cerebral Circulation·R G HartD Hart
May 1, 1994·Stroke; a Journal of Cerebral Circulation·S M LaiE Sobel
May 1, 1993·Journal of Studies on Alcohol·B G Embree, P C Whitehead
Aug 1, 1997·Controlled Clinical Trials·H P AdamsK J Grimsman
Oct 2, 1998·Stroke; a Journal of Cerebral Circulation·J T MoroneyD W Desmond
Oct 17, 1998·Cerebrovascular Diseases·A ArboixC Targa
Jan 9, 2001·JAMA : the Journal of the American Medical Association·S C JohnstonS Sidney

❮ Previous
Next ❯

Citations

Mar 3, 2009·Journal of Neurology·J CastilloUNKNOWN MITICO Study Investigators
Aug 10, 2007·International Journal of Clinical Practice·M E FalagasP I Vergidis
Feb 28, 2008·Cerebrovascular Diseases·Soo Kyoung KimGyeong-Moon Kim
Oct 20, 2010·Vascular Health and Risk Management·Nicole M Engel-NitzHemal Shah
Nov 29, 2007·Acta Neurologica Scandinavica·G TelmanD Yarnitsky
Aug 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Mahnaz Fatahzadeh, Michael Glick
Nov 15, 2008·Stroke; a Journal of Cerebral Circulation·Omer SakaCharles C D A Wolfe
May 3, 2008·Current Opinion in Neurology·Manuel Rodríguez-Yáñez, José Castillo
Jun 11, 2009·Journal of Clinical Neurology·Su-Yun LeeJae-Kwan Cha
Apr 9, 2019·Journal of the American Heart Association·Jingjing ChenGelin Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.