Abstract
The prevention of early recurrent stroke, which worsens outcomes after a cerebral infarction, is a major objective for acute stroke therapy. The ability to predict which patients are at risk for early recurrence would be useful for both the management and design of clinical trials. Using the prospective database with the 1,266 stroke patients admitted in the TOAST study, we analyzed all the patients who had suffered either a transient ischemic attack (TIA) or a recurrent stroke within 3 months after stroke, and their possible association with 20 selected clinical variables. Both univariate and stepwise regression analyses were performed. Sixty-two patients (4.9%) had a second stroke, and 47 patients (3.7%) had at least one TIA. No particular high-risk period was observed. Early recurrent stroke was associated with the large artery atherosclerosis subtype. A prior history of TIA increased the odds for recurrent stroke (OR = 2.52; 1.16-5.46) or poststroke TIA (OR = 3.46; 1.59-7.48). In addition, patients who had a TIA after the stroke had a 17% chance of having an early recurrent stroke, as compared with 4.4% among those that did not (p = 0.001). Our present ability to identify patients at risk for early recurrence based on basel...Continue Reading
References
Jul 1, 1992·Stroke; a Journal of Cerebral Circulation·L B Goldstein, A Perry
Jun 22, 1991·Lancet·J BamfordC Warlow
May 1, 1989·Neurology·E SobelT Isack
Aug 1, 1989·Stroke; a Journal of Cerebral Circulation·R L SaccoT R Price
Jan 1, 1987·Stroke; a Journal of Cerebral Circulation·P B Gorelick
Mar 1, 1987·Neurology·M AlterE F Meehan
Sep 1, 1983·Stroke; a Journal of Cerebral Circulation·R G HartD Hart
Nov 1, 1995·Neurology·K P MaddenW R Clarke
Jan 1, 1993·Stroke; a Journal of Cerebral Circulation·H P AdamsE E Marsh
May 1, 1994·Stroke; a Journal of Cerebral Circulation·S M LaiE Sobel
May 1, 1993·Journal of Studies on Alcohol·B G Embree, P C Whitehead
Apr 1, 1997·Neurology·H S JørgensenT S Olsen
Aug 1, 1997·Controlled Clinical Trials·H P AdamsK J Grimsman
May 2, 1998·JAMA : the Journal of the American Medical Association
Oct 2, 1998·Stroke; a Journal of Cerebral Circulation·J T MoroneyD W Desmond
Oct 17, 1998·Cerebrovascular Diseases·A ArboixC Targa
Jan 9, 2001·JAMA : the Journal of the American Medical Association·S C JohnstonS Sidney
Jan 29, 2003·Neurology·S Claiborne JohnstonDaryl R Gress
Citations
Mar 3, 2009·Journal of Neurology·J CastilloUNKNOWN MITICO Study Investigators
Aug 10, 2007·International Journal of Clinical Practice·M E FalagasP I Vergidis
Feb 28, 2008·Cerebrovascular Diseases·Soo Kyoung KimGyeong-Moon Kim
Feb 25, 2009·BMC Neurology·Olive Lennon, Catherine Blake
Oct 20, 2010·Vascular Health and Risk Management·Nicole M Engel-NitzHemal Shah
Nov 29, 2007·Acta Neurologica Scandinavica·G TelmanD Yarnitsky
Aug 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Mahnaz Fatahzadeh, Michael Glick
Nov 15, 2008·Stroke; a Journal of Cerebral Circulation·Omer SakaCharles C D A Wolfe
May 3, 2008·Current Opinion in Neurology·Manuel Rodríguez-Yáñez, José Castillo
Jun 11, 2009·Journal of Clinical Neurology·Su-Yun LeeJae-Kwan Cha
Apr 9, 2019·Journal of the American Heart Association·Jingjing ChenGelin Xu