Can we predict real T3 stage prostate cancer in patients with clinical T3 (cT3) disease before radical prostatectomy?

Yonsei Medical Journal
Hye Won LeeHan Yong Choi

Abstract

Down-staging of clinical T3 (cT3) prostate cancer after radical prostatectomy (RP) is not uncommon due to the inaccuracy of the currently available staging modalities, although selected down-staged cT3 patients can be a candidate for definitive RP. We identified the significant predictors for down-staging of cT3 after RP. We included 67 patients with cT3 stage prostate cancer treated with radical perineal prostatectomy (RPP) between 1998 and 2006 and reviewed their medical records retrospectively. The clinical stage was obtained according to the DRE, the prostate biopsy findings, and the prostate MRI. Fifty three (79%) patients with cT3 prostate cancer were down-staged to pT2 after RP. The percent of positive cores had the strongest association with down-staging of cT3 [p = 0.01, odds ratio (OR) = 6.3], followed by baseline prostate specific antigen (PSA) (p = 0.03, OR = 5.0), the biopsy Gleason sum (GS) (p = 0.03, OR = 4.7), and the maximum tumor volume of the positive cores (p = 0.05, OR = 4.0). When the cut-off points of significant parameters which were a PSA < 10 ng/mL, a percent of positive cores < or = 30%, a maximum tumor volume of the positive cores < or = 75% and GS < or = 7 were combined, the sensitivity, specificity...Continue Reading

References

Mar 1, 1994·The Journal of Urology·D van den OudenF H Schröder
Aug 5, 2000·World Journal of Urology·T ReckwitzA W Partin
Aug 27, 2002·European Radiology·Marc R EngelbrechtJelle O Barentsz
Feb 23, 2007·Cancer·Stephen J FreedlandPatrick C Walsh
Aug 11, 2007·European Journal of Radiology·Jurgen J Fütterer

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Citations

May 21, 2014·Nature Reviews. Clinical Oncology·Linda M JohnsonPeter L Choyke
Jan 11, 2014·Asian Journal of Andrology·Young Hwii KoDeuk Jae Sung
Jul 6, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Minh DoJens-Uwe Stolzenburg
Mar 21, 2015·Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society·Mahyar GhafooriKamal Hoseini

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Methods Mentioned

BETA
biopsy
biopsies
dissection
imaging techniques

Software Mentioned

SPSS

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