Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Brooke L FarrugiaJohn Whitelock

Abstract

Heparan sulfate (HS) and heparin are glycosaminoglycans (GAGs) that are heterogeneous in nature, not only due to differing disaccharide combinations, but also their sulfate modifications. HS is well known for its interactions with various growth factors and cytokines; and heparin for its clinical use as an anticoagulant. Due to their potential use in tissue regeneration; and the recent adverse events due to contamination of heparin; there is an increased surge to produce these GAGs on a commercial scale. The production of HS from natural sources is limited so strategies are being explored to be biomimetically produced via chemical; chemoenzymatic synthesis methods and through the recombinant expression of proteoglycans. This review details the most recent advances in the field of HS/heparin synthesis for the production of low molecular weight heparin (LMWH) and as a tool further our understanding of the interactions that occur between GAGs and growth factors and cytokines involved in tissue development and repair.

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Citations

Oct 30, 2016·Metabolic Engineering·Megan S LordJohn M Whitelock
Nov 2, 2016·Analytical Chemistry·Rebecca L MillerJeremy E Turnbull
Dec 29, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vito Ferro
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Apr 15, 2020·Nature Biomedical Engineering·Megan LordJeremy E Turnbull
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May 16, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ha Na KimMegan S Lord
Oct 17, 2016·Glycobiology·Yanlei YuRobert J Linhardt
Sep 19, 2020·Drug Discovery Today·Sultan N Baytas, Robert J Linhardt

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Methods Mentioned

BETA
glycosylation
transfection

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