Can we protect from malignant arrhythmias by modulation of cardiac cell-to-cell coupling?

Journal of Electrocardiology
N TribulováCsilla Viczenczova

Abstract

Defects in intercellular coupling in the heart play a key role in the initiation and persistence of malignant arrhythmias. Such disorders result from abnormal expression and distribution of connexins, the major constituents of cardiac gap junction channels. The alterations of myocardial connexin are well established as a consistent feature of both human and animal heart disease and aging. Following these facts, the modulation of connexin mediated intercellular coupling is suggested as a new antiarrhythmic approach. This review provides recent data supporting this concept. It can be challenging for the development of new antiarrhythmic drugs. Moreover, findings point out the implication of some endogenous compounds in protection from life-threatening arrhythmias via preservation of myocardial connexin.

References

Jul 1, 1982·Circulation Research·W C De Mello
Jun 18, 2002·Journal of Cellular and Molecular Medicine·N J Severs
Mar 27, 2004·Physiological Reviews·André G Kléber, Yoram Rudy
Apr 20, 2004·Cardiovascular Research·Ben N G Giepmans
Oct 23, 2004·Circulation Research·Stephan B DanikDavid E Gutstein
May 17, 2005·American Journal of Physiology. Heart and Circulatory Physiology·David E GutsteinGlenn I Fishman
May 19, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Stefan DheinFriedrich-Wilhelm Mohr
Feb 24, 2007·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Walmor C De Mello, Philip Specht
Sep 12, 2007·Basic & Clinical Pharmacology & Toxicology·Anne Louise KjølbyeJørgen S Petersen
Oct 9, 2007·Journal of the American College of Cardiology·Jean-Francois SarrazinFranck Molin
Nov 28, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Stefan DheinFriedrich-Wilhelm Mohr
Dec 30, 2009·The Journal of Clinical Investigation·Gordon F Tomaselli
Dec 30, 2009·The Journal of Clinical Investigation·James W SmythRobin M Shaw
Nov 19, 2011·Journal of the American College of Cardiology·Ali A SovariSamuel C Dudley
Aug 14, 2012·Journal of the American College of Cardiology·Ian D GreenerJ Kevin Donahue
Mar 8, 2013·Toxicology·Yu-Sen PengSeu-Mei Wang
Apr 6, 2013·Circulation. Arrhythmia and Electrophysiology·Ali A SovariSamuel C Dudley
Dec 24, 2013·Journal of the American College of Cardiology·Cody A RutledgeSamuel C Dudley
Mar 13, 2014·Circulation. Arrhythmia and Electrophysiology·Paramdeep S DhillonNicholas S Peters
Apr 10, 2014·Free Radical Biology & Medicine·Kai-Chien YangSamuel C Dudley

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Citations

Nov 22, 2017·International Journal of Molecular Sciences·Emma Katengua-ThamahaneNarcis Tribulova
Oct 31, 2017·Nutrients·Narcis TribulovaJan Slezak
Jun 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tyler W LeBaronJan Slezak
May 2, 2017·Canadian Journal of Physiology and Pharmacology·Csilla ViczenczovaJan Slezak
Jan 2, 2020·International Journal of Molecular Sciences·Said MasoudKatja Rietdorf
Apr 13, 2018·International Journal of Molecular Sciences·Csilla ViczenczovaBarbara Szeiffova Bacova
Aug 4, 2019·International Journal of Molecular Sciences·Matus SykoraNarcis Tribulova
Jan 18, 2020·International Journal of Molecular Sciences·Barbara Szeiffova BacovaNarcis Tribulova
Apr 25, 2020·International Journal of Molecular Sciences·Narcis TribulovaBarbara Szeiffova Bacova
Jan 2, 2021·International Journal of Molecular Sciences·Katarina AndelovaNarcis Tribulova
Jun 3, 2021·Journal of Cardiovascular Development and Disease·Konstantinos C ZekiosTheofilos M Kolettis

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