PMID: 25798161Mar 24, 2015Paper

Canadian Public Health Laboratory Network laboratory guidelines for the diagnosis of neurosyphilis in Canada

The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale
Tom WongBouchra Serhir

Abstract

Neurosyphilis refers to infection of the central nervous system by Treponema pallidum, which may occur at any stage. Neurosyphilis has been categorized in many ways including early and late, asymptomatic versus symptomatic and infectious versus non-infectious. Late neurosyphilis primarily affects the central nervous system parenchyma, and occurs beyond early latent syphilis, years to decades after the initial infection. Associated clinical syndromes include general paresis, tabes dorsalis, vision loss, hearing loss and psychiatric manifestations. Unique algorithms are recommended for HIV-infected and HIV-uninfected patients, as immunocompromised patients may present with serologic and cerebrospinal fluid findings that are different from immunocompetent hosts. Antibody assays include a VDRL assay and the FTA-Abs, while polymerase chain reaction for T. pallidum can be used as direct detection assays for some specimens. This chapter reviews guidelines for specimen types and sample collection, and identifies two possible algorithms for use with immunocompromised and immunocompetent hosts using currently available tests in Canada, along with a review of treatment response and laboratory testing follow-up.

Citations

Nov 5, 2016·International Journal of STD & AIDS·Chang-Wan Kim, Chang-Rack Lee
Feb 22, 2017·Acta Clinica Belgica·Sévérine de BruijnErika Vlieghe
Nov 9, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·S ZhengC C L Ngan
Oct 29, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Derya Ozturk-EnginHaluk Vahaboglu
Dec 15, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·M ShiP Zhou
Jan 14, 2021·Sexually Transmitted Infections·Dongdong LiChuanmin Tao
Nov 5, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Li-Rong LinTian-Ci Yang
Jun 24, 2016·Microbiology Spectrum·Andrea J ZimmerKaren C Bloch

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