Canal-otolith interactions in the squirrel monkey vestibulo-ocular reflex and the influence of fixation distance

Experimental Brain Research
L TelfordG D Paige

Abstract

Natural head movements include angular and linear components of motion. Two classes of vestibulo-ocular reflex (VOR), mediated by the semicircular canals and otoliths (the angular and linear VOR, or AVOR and LVOR, respectively), compensate for head movements and help maintain binocular fixation on targets in space. In this study, AVOR/LVOR interactions were quantified during complex head motion over a broad range of fixation distances at a fixed stimulus frequency of 4.0 Hz. Binocular eye movements were recorded (search-coil technique) in squirrel monkeys while fixation distance (assessed by vergence) was varied using brief presentations of earth-fixed targets at various distances. Stimuli consisted of rotations around an earth-vertical axis and therefore always activated the AVOR. Horizontal and vertical AVORs were assessed when the head was centered over the axis of rotation and oriented upright (UP) and right-side-down (RD), respectively. AVOR gains increased slightly with increasing vergence in darkness, as expected given the small anterior position of the eyes in the head. Combined AVOR/LVOR responses were recorded when subjects were displaced eccentrically from the rotation axis. Eccentric rotations activated the AVOR jus...Continue Reading

Citations

Oct 31, 2007·Experimental Brain Research·Claire C Gianna-Poulin, Robert J Peterka
Nov 9, 2007·Experimental Brain Research·Ke LiaoR John Leigh
Jan 12, 2008·Experimental Brain Research·Americo A MigliaccioJohn P Carey
Jan 23, 1999·Current Opinion in Neurobiology·J L Raymond
Jun 18, 1999·Annals of the New York Academy of Sciences·G D Paige, S H Seidman
Apr 19, 2002·Annals of the New York Academy of Sciences·Gary D Paige
Jul 18, 2008·Journal of Neurophysiology·Kimberly L McArthur, J David Dickman
Nov 13, 2004·Vision Research·John S Stahl
Dec 2, 2005·Journal of Neurophysiology·R A A VingerhoetsJ A M Van Gisbergen
Apr 4, 2003·Journal of Neurophysiology·Stefano Ramat, David S Zee
Nov 9, 2002·Journal of Neurophysiology·Keisuke KushiroTheodore Raphan
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Dec 9, 2000·Journal of Neurophysiology·W P MedendorpC C Gielen
Nov 17, 2001·Annals of the New York Academy of Sciences·T RaphanB Cohen

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