Canalization and developmental stability in the Brachyrrhine mouse

Journal of Anatomy
Katherine WillmoreBenedikt Hallgrímsson

Abstract

The semi-dominant Br mutation affects presphenoid growth, producing the facial retrognathism and globular neurocranial vault that characterize heterozygotes. We analysed the impact of this mutation on skull shape, comparing heterozygotes to wildtype mice, to determine if the effects are skull-wide or confined to the sphenoid region targeted by the mutation. In addition, we examined patterns of variability of shape for the skull as a whole and for three regions (basicranium, face and neurocranium). We found that the Br mice differed significantly from wildtype mice in skull shape in all three regions as well as in the shape of the skull as a whole. However, the significant increases in variance and fluctuating asymmetry were found only in the basicranium of mutant mice. These results suggest that the mutation has a significant effect on the underlying developmental architecture of the skull, which produces an increase in phenotypic variability that is localized to the anatomical region in which the mean phenotype is most dramatically affected. These results suggest that the same developmental mechanisms that produce the change in phenotypic mean also produce the change in variance.

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Citations

Sep 1, 2008·Integrative and Comparative Biology·Christopher J Vinyard, Bret A Payseur
Sep 1, 2008·Integrative and Comparative Biology·Benedikt Hallgrímsson, Daniel E Lieberman
Dec 22, 2006·PloS One·Casper J BreukerChristian Peter Klingenberg
Jun 13, 2009·Progress in Retinal and Eye Research·Paul G SanfilippoDavid A Mackey
Nov 22, 2008·Evolution & Development·Miriam Leah ZelditchDonald L Swiderski
Dec 20, 2008·Journal of Anatomy·Julia C BoughnerBenedikt Hallgrímsson
Mar 19, 2013·American Journal of Physical Anthropology·John M StarbuckJoan T Richtsmeier
Jun 4, 2014·American Journal of Physical Anthropology·Paula N GonzalezBenedikt Hallgrímsson
Jul 16, 2008·Developmental Biology·W James Cooper, R Craig Albertson
May 23, 2013·Journal of Anatomy·Hester BaverstockSamuel N Cobb
Feb 28, 2019·Frontiers in Genetics·Ceferino Varón-GonzálezNicolas Navarro
Oct 12, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Timothy D SmithValerie B DeLeon
Oct 2, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Andrea CardiniThomas M Butynski

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