Canalization Leads to Similar Whole Bone Mechanical Function at Maturity in Two Inbred Strains of Mice

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Stephen H SchlechtKarl J Jepsen

Abstract

Previously, we showed that cortical mineralization is coordinately adjusted to mechanically offset external bone size differences between A/J (narrow) and C57BL/6J (wide) mouse femora to achieve whole bone strength equivalence at adulthood. The identity of the genes and their interactions that are responsible for establishing this homeostatic state (ie, canalization) remain unknown. We hypothesize that these inbred strains, whose interindividual differences in bone structure and material properties mimic that observed among humans, achieve functional homeostasis by differentially adjusting key molecular pathways regulating external bone size and mineralization throughout growth. The cortices of A/J and C57BL/6J male mouse femora were phenotyped and gene expression levels were assessed across growth (ie, ages 2, 4, 6, 8, 12, 16 weeks). A difference in total cross-sectional area (p < 0.01) and cortical tissue mineral density were apparent between mouse strains by age 2 weeks and maintained at adulthood (p < 0.01). These phenotypic dissimilarities corresponded to gene expression level differences among key regulatory pathways throughout growth. A/J mice had a 1.55- to 7.65-fold greater expression among genes inhibitory to Wnt path...Continue Reading

References

Apr 1, 1965·Animal Behaviour·W M Fox
May 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K J JepsenJ Bonadio
Apr 5, 2000·The Journal of Clinical Investigation·A M DelanyE Canalis
May 3, 2000·The Journal of Clinical Investigation·A M DelanyE Canalis
May 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K D HankensonP Bornstein
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K J JepsenJ Nadeau
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 30, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laurent AmeyeMarian F Young
Jun 25, 2002·Trends in Neurosciences·David P WolferHans Peter Lipp
Feb 14, 2003·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Karl J JepsenJoseph H Nadeau
Aug 30, 2005·Gene·Xu Cao, Di Chen
Oct 20, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christopher PriceKarl J Jepsen
May 4, 2006·The Journal of Clinical Investigation·Venkatesh KrishnanOrmond A Macdougald
Jun 9, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Karl J JepsenJoseph H Nadeau
Dec 20, 2007·The Journal of Biological Chemistry·Alexander G RoblingCharles H Turner
Dec 21, 2007·Journal of Bone and Mineral Metabolism·Ego Seeman
Sep 5, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Charles R FarberAldons J Lusis
Dec 17, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Karl J JepsenJoseph H Nadeau
Dec 17, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nirnimesh PandeyKarl J Jepsen
Mar 20, 2010·Proceedings. Biological Sciences·Elizabeth R Dumont
Jul 2, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Desmond PadhiEdward Posvar
Mar 10, 2011·Nature Reviews. Rheumatology·James R Edwards, Gregory R Mundy
May 28, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S KirmaniS Khosla
Sep 8, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Karl J JepsenRachel K Evans
Dec 23, 2011·Nature Reviews. Molecular Cell Biology·Fanxin Long
Feb 22, 2012·Critical Reviews in Eukaryotic Gene Expression·Peter S N Rowe
Oct 2, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Liesbet Lieben, Geert Carmeliet
Jan 15, 2013·G3 : Genes - Genomes - Genetics·Charles R Farber
Feb 8, 2013·Nature Medicine·Roland Baron, Michaela Kneissel
Sep 3, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Juliet McColmAlan Y Chiang
Jan 3, 2014·The New England Journal of Medicine·Michael R McClungHenry G Bone
Mar 1, 2014·BoneKEy Reports·Bart L Clarke, Matthew T Drake
May 14, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A MorseD G Little
Sep 28, 2014·Bioinformatics·Simon AndersWolfgang Huber
Feb 19, 2015·Clinical Orthopaedics and Related Research·Karl J JepsenStephen H Schlecht

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Citations

May 2, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stephen H SchlechtJames A Ashton-Miller
Jul 1, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Daniella M PattonStephen H Schlecht

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