PMID: 26343109Sep 8, 2015Paper

Cancer: A Problem of Developmental Biology; Scientific Evidence for Reprogramming and Differentiation Therapy

Current Drug Targets
S SellP M Biava

Abstract

Current medical literature acknowledges that embryonic micro-environment is able to suppress tumor development. Administering carcinogenic substances during organogenesis in fact leads to embryonic malformations, but not to offspring tumor growth. Once organogenesis has ended, administration of carcinogenic substances causes a rise in offspring tumor development. These data indicate that cancer can be considered a deviation in normal development, which can be regulated by factors of the embryonic microenvironment. Furthermore, it has been demonstrated that teratoma differentiates into normal tissues once it is implanted in the embryo. Recently, it has been shown that implanting a melanoma in Zebrafish embryo did not result in a tumor development; however, it did in the adult specimen. This demonstrates that cancer cells can differentiate into normal tissues when implanted in the embryo. In addition, it was demonstrated that other tumors can revert into a normal phenotype and/or differentiate into normal tissue when implanted in the embryo. These studies led some authors to define cancer as a problem of developmental biology and to predict the present concept of "cancer stem cells theory". In this review, we record the most impo...Continue Reading

Citations

Feb 23, 2018·Cell Death & Disease·Emira AyroldiCarlo Riccardi
Dec 17, 2015·Digestive Diseases and Sciences·Yanning LiHui Wang
May 6, 2019·Current Treatment Options in Oncology·Ion G Motofei
Oct 21, 2020·Biomolecules & Therapeutics·Dong Wook Shin
Dec 22, 2020·Frontiers in Cell and Developmental Biology·Liming YuChao Deng
Aug 11, 2021·Cell Communication and Signaling : CCS·Yingjie QingHui Hui
Feb 1, 2020·Current Medicinal Chemistry·Jie ZhangWenjie Zheng

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