Cancer and aging: Epidemiology and methodological challenges

Acta Oncologica
Jacob K PedersenAcademy of Geriatric Cancer Research (AgeCare)

Abstract

Epidemiological cancer data shed light on key questions within basic science, clinical medicine and public health. For decades, Denmark has had linkable health registers that contain individual level data on the entire population with virtually complete follow-up. This has enabled high quality studies of cancer epidemiology and minimized the challenges often faced in many countries, such as uncertain identification of the study base, age misreporting, and low validity of the cancer diagnoses. However, methodological challenges still remain to be addressed, especially in cancer epidemiology studies among the elderly and the oldest-old. For example, a characteristic pattern for many cancer types is that the incidence increases up to a maximum at about ages 75-90 years and is then followed by a decline or a leveling off at the oldest ages. It has been suggested that the oldest individuals may be asymptomatic, or even insusceptible to cancer. An alternative interpretation is that this pattern is an artifact due to lower diagnostic intensity among the elderly and oldest-old caused by higher levels of co-morbidities in this age group. Currently, the available cancer epidemiology data are not able to provide clear evidence for any of ...Continue Reading

References

Apr 1, 1996·Cancer·D W Smith
Jan 10, 2002·Nature·Stuart D TynerLawrence A Donehower
Dec 2, 2004·Journal of the American Geriatrics Society·Dellara F TerryThomas T Perls
Aug 19, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elizabeth O'BrienDiana Lane Reed
May 31, 2008·American Journal of Public Health·Francis P Boscoe
May 13, 2009·Medical Care·Steven P WallaceXóchitl Castañeda
Oct 6, 2009·Lancet·Kaare ChristensenJames W Vaupel
Apr 30, 2010·Rejuvenation Research·Svetlana V UkraintsevaAnatoli I Yashin
Aug 4, 2011·Scandinavian Journal of Public Health·Karin Helweg-Larsen
Aug 4, 2011·Scandinavian Journal of Public Health·Marianne Lundkjær Gjerstorff
Sep 20, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mats Talbäck, Paul W Dickman
Sep 29, 2011·Cancer·Charles HardingRichard Wilson
Apr 5, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kaare ChristensenAxel Skytthe
May 25, 2013·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Irma T EloThomas Perls

❮ Previous
Next ❯

Citations

Jan 20, 2016·Acta Oncologica·Marianne EwertzUNKNOWN Academy of Geriatric Cancer Research (AgeCare)
May 16, 2017·Mechanisms of Ageing and Development·Shantell C NolenDaniela A Bota
Feb 22, 2017·Journal of Neurology·Angela RosenbohmUNKNOWN ALS Registry Study Group
Sep 27, 2018·International Journal of Epidemiology·Silvia RizziRune Lindahl-Jacobsen
Apr 23, 2019·Journal of the American Geriatrics Society·Heidi D Klepin, Tanya M Wildes
Apr 26, 2018·Anti-cancer Agents in Medicinal Chemistry·Vivian M RumjanekPaulo R R Costa
Oct 9, 2019·Aging Clinical and Experimental Research·Anna TampieriSimone Sprio
Sep 12, 2018·European Journal of Public Health·Eira T RoosOssi Rahkonen
Oct 23, 2020·American Journal of Epidemiology·Tomas TanskanenJanne M Pitkäniemi
May 3, 2019·Case Reports in Oncology·Emilio Conde-FloresJose Manuel Ruiz-Morales

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Related Papers

BMJ : British Medical Journal
D M Campbell
Acta - Unio Internationalis Contra Cancrum
J CLEMMESEN
Ugeskrift for laeger
Kasper Jørgensen, Gunhild Waldemar
Ugeskrift for laeger
M Ewertz, H Møller
© 2021 Meta ULC. All rights reserved