PMID: 18719390Aug 23, 2008Paper

Cancer and aging: more puzzles, more promises?

Cell Cycle
Mikhail V Blagosklonny, Judith Campisi

Abstract

In this issue of Cell Cycle, a new paper shows that metformin, an oral antidiabetic drug that activates AMP-activated protein kinase, prolongs both mean and maximal life span and prevents reproductive aging of female mice. Unexpectedly, metformin did not decrease the incidence of cancer in this mice strain. Here, we discuss the relationship between aging and cancer, the mechanism of metformin action, and the prospects of using this compound for life span extension in humans.

Citations

Nov 26, 2008·Nature Reviews. Cancer·Michael Pollak
Apr 21, 2009·Future Oncology·Lev M Berstein
Oct 21, 2010·Cellular and Molecular Life Sciences : CMLS·Zelton Dave Sharp
Feb 16, 2010·Expert Opinion on Emerging Drugs·James A McCubreyMelchiorre Cervello
Feb 6, 2013·PloS One·Joseph T GlessnerHakon Hakonarson
Jan 27, 2012·PloS One·Paola SebastianiThomas T Perls
Feb 25, 2011·PloS One·Carmen M KochWolfgang Wagner
Jun 5, 2010·PLoS Genetics·Matthew A SchreiberSteven L McIntire
Apr 13, 2011·Aging·Javier A MenendezAlejandro Vazquez-Martin
Jan 1, 2014·Frontiers in Molecular Biosciences·Anton A BuzdinNikolay M Borisov
Mar 5, 2013·Aging·Carolina B LiviZelton Dave Sharp
Jul 16, 2014·Oncotarget·Zaid Al-WahabRamandeep Rattan

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