Cancer and blood coagulation

Cellular and Molecular Life Sciences : CMLS
C Boccaccio, E Medico

Abstract

In human patients, blood coagulation disorders often associate with cancer, even in its early stages. Recently, in vitro and in vivo experimental models have shown that oncogene expression, or inactivation of tumour suppressor genes, upregulate genes that control blood coagulation. These studies suggest that activation of blood clotting, leading to peritumoral fibrin deposition, is instrumental in cancer development. Fibrin can indeed build up a provisional matrix, supporting the invasive growth of neoplastic tissues and blood vessels. Interference with blood coagulation can thus be considered as part of a multifaceted therapeutic approach to cancer.

Citations

Jan 5, 2008·Cancer Metastasis Reviews·Alessandra GentilePaolo M Comoglio
Oct 2, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Henry N JabbourJane E Norman
Nov 22, 2014·Scientific Reports·Samridhi SharmaSanjeeva Srivastava
May 7, 2013·Thrombosis Research·Bertrand RaynalMattia Rocco
Mar 12, 2013·Biophysical Journal·Davide MagattiFabio Ferri
Jul 2, 2016·Macromolecular Bioscience·A Puiggalí-JouCarlos Alemán
Aug 12, 2018·Nature Communications·Rajeswara Rao ArasadaDavid P Carbone
Mar 14, 2018·Molecular Medicine Reports·Fucai TangHangtao Wang
Aug 18, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Aleksandra M KusovaYuriy F Zuev

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