Cancer and blood concentrations of the comutagen harmane in essential tremor.

Movement Disorders : Official Journal of the Movement Disorder Society
Elan D LouisWei Zheng

Abstract

Blood concentrations of harmane, a tremor-producing neurotoxin, are elevated in essential tremor (ET). Harmane is also a comutagen. Using a case-control design, we compared the prevalence of cancer in ET cases vs. controls, and determined whether blood harmane concentrations are elevated among ET cases with cancer. 66/267 (24.7%) ET cases vs. 55/331 (16.6%) controls had cancer (adjusted OR 1.52, 95% CI 1.01-2.30, P = 0.04). Among specific cancer types, colon cancer was more prevalent in ET cases than controls (2.6% vs. 0.6%, P = 0.04). Log blood harmane concentration was higher in ET cases vs. controls (P = 0.02) and in participants with vs. without cancer (P = 0.02). Log blood harmane concentration was highest in ET cases with cancer when compared with other groups (P = 0.009). These links between cancer and ET and between high blood harmane and cancer in ET deserve further study.

References

May 1, 1968·Journal of the American Geriatrics Society·B S LinnL Gurel
Feb 1, 1983·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M RoyA Barbeau
Oct 1, 1995·Mutation Research·C de Meester
Apr 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M BoissetJ F Desjeux
Dec 8, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Fredricka C MartinAdrian Handforth
Oct 26, 2005·Neuropharmacology·Neil J AndersonEmma S J Robinson
Jan 17, 2007·Prostate Cancer and Prostatic Diseases·K T BogenE A Holly
Jan 26, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Harvey J ArmbrechtTerry V Zenser
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Roberto ZanettiDora I Loria
Oct 2, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Udo BonnetMartin Wiemann

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Citations

Mar 24, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E D LouisUNKNOWN Neurological Disorders in Central Spain (NEDICES) Study Group
Jul 30, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Raymond Y LoLorene M Nelson
Aug 25, 2010·Toxicology and Applied Pharmacology·Mohamed A M El Gendy, Ayman O S El-Kadi

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