PMID: 11908507Mar 23, 2002Paper

Cancer and the prothrombotic state

The Lancet Oncology
Gregory Y H LipA D Blann

Abstract

Thrombosis is a frequent complication of cancer, so it follows that the presence of a tumour confers a prothrombotic state. Indeed, in patients with cancer, each of the three components of Virchow's triad that predispose for thrombus formation have abnormalities, thus fulfilling the requirement for a prothrombotic or hypercoagulable state. The many signs and symptoms of the prothrombotic state in cancer range from asymptomatic basic abnormal coagulation tests to massive clinical thromboembolism, when the patient may be gravely ill. Many procoagulant factors, such as tissue factor and cancer procoagulant, are secreted by or are expressed at the cell surface of many tumours. Platelet turnover and activity are also increased. Damaged endothelium and abnormalities of blood flow in cancer also seem to play a part, as does abnormal tumour angiogenesis. Some studies have even suggested that these abnormalities may be related to long-term prognosis and treatment. We briefly describe the various clinical manifestations of thrombosis in cancer and discuss the evidence for the existence of a prothrombotic or hypercoagulable state associated with this disease. Further work is needed to examine the mechanisms leading to the prothrombotic st...Continue Reading

References

Dec 1, 1976·American Heart Journal·L M Deppisch, A O Fayemi
Jan 1, 1992·Seminars in Thrombosis and Hemostasis·S M Scates
Oct 15, 1992·The New England Journal of Medicine·P PrandoniJ W ten Cate
Nov 1, 1990·The American Journal of the Medical Sciences·J C ChangN S Jang
Jan 1, 1991·Japanese Journal of Cancer Research : Gann·K HoriS Saito
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P McCullochW D George
Jan 3, 1987·British Medical Journal·S Heptinstall
Jan 24, 1987·British Medical Journal·A E Mourant
Aug 1, 1987·Kidney International·G Remuzzi
Feb 18, 1988·The New England Journal of Medicine·M N LevineS De Pauw
Jul 1, 1984·Annals of Internal Medicine·A M JacksonR G Narins
May 1, 1981·Journal of Clinical Pathology·J StuartR A Hurlow
Jan 1, 1994·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A FalangaT Barbui
Sep 1, 1994·The Journal of Clinical Investigation·Y ZhangP P Nawroth
Aug 1, 1995·The British Journal of Surgery·A K KakkarR C Williamson
Apr 1, 1993·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·R SeitzK Havemann
Feb 1, 1996·Journal of Internal Medicine·E A BastounisE L Papalambros
May 1, 1997·Haemostasis·D GreenG A Soff
Aug 5, 1998·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A D Blann, G Y Lip
Jun 15, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J BussinkA J van der Kogel
Mar 7, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A D BlannG Y Lip
Sep 29, 2001·BMJ : British Medical Journal·T Fennerty

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Citations

Jun 18, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ignasio Gil-BazoJesús García-Foncillas López
Nov 18, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Lee NewkirkErnest Conrad
Oct 6, 2007·Clinical Reviews in Allergy & Immunology·Eyal Reinstein, Yehuda Shoenfeld
Apr 27, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Evren FidanFazil Aydin
Mar 30, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·W Z XieF Gieseler
Feb 18, 2004·Thrombosis Research·Anders MälarstigAgneta Siegbahn
Oct 10, 2002·The Lancet Oncology·Graham J Caine, Gregory Y H Lip
May 19, 2005·Journal of the National Cancer Institute·Ariane DienstClaudia Gottstein
May 30, 2013·Plastic and Reconstructive Surgery·Morteza EnajatMarc A M Mureau
Jan 28, 2006·BMJ : British Medical Journal·Andrew D Blann, Gregory Y H Lip
Oct 28, 2006·Postgraduate Medical Journal·A Fennerty
Sep 3, 2005·Oncology·József TímárKároly Lapis
May 18, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·O KaftanS K Yalcin
Dec 13, 2005·Thrombosis Journal·Maike UnruhClaudia Gottstein
Dec 29, 2010·International Journal of Nanomedicine·Yi-ling LuZong-ning Yin
Feb 28, 2007·Vascular Health and Risk Management·Ozlem Er, Leo Zacharski
Dec 18, 2010·Drugs·Manuel Monreal BoschPaolo Prandoni
Apr 17, 2007·Journal of Neurosurgery·Thomas J SemradRichard H White
Mar 16, 2011·Cardiology Research and Practice·Andrew D Blann, Simon Dunmore
Jan 15, 2011·Cardiology Research and Practice·Ali ZalpourSyed Wamique Yusuf
Jul 11, 2013·Nanomedicine·Yanping DingGuangjun Nie
May 19, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Gabriele HinterhuberPeter Quehenberger
May 30, 2014·American Journal of Epidemiology·Morten OlsenHenrik Toft Sørensen
Sep 17, 2013·Current Hematologic Malignancy Reports·Guido FinazziTiziano Barbui
May 6, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yen-Nien LinChia-Hung Kao
Aug 19, 2009·Annals of Hematology·Wouter RavenFrank W G Leebeek
Oct 17, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Miao YuYi-Qing Li
Mar 11, 2003·Journal of Women's Health·Julie T Lin, Elisabeth Lachmann
Jan 23, 2013·Neurological Research·Kaisorn L ChaichanaAlfredo Quinones-Hinojosa
Jan 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fan ZhangJie He
Apr 20, 2012·Biochimica Et Biophysica Acta·Subhankar ChakrabortySurinder K Batra
Jan 31, 2012·The Veterinary Clinics of North America. Small Animal Practice·Michael O Childress
Jan 26, 2011·Thrombosis Research·Alexander T CohenJoel Vincente Solis
Feb 1, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Kazuo YamashiroYasuyuki Okuma
Mar 12, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lisa Barbera, Gillian Thomas
Apr 24, 2009·Autoimmunity Reviews·A TincaniR Cattaneo
Feb 3, 2009·Autoimmunity Reviews·Ernesto de MeisRoger A Levy
Dec 3, 2008·European Journal of Internal Medicine·Engin YigitBurcu Cakar

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