Cancer antigen profiling for malignant pleural mesothelioma immunotherapy: expression and coexpression of mesothelin, cancer antigen 125, and Wilms tumor 1

Oncotarget
Takashi EguchiPrasad S Adusumilli

Abstract

To develop cancer antigen-targeted immunotherapeutic strategies for malignant pleural mesothelioma (MPM), we investigated the individual and coexpressions of the cancer-associated antigens mesothelin (MSLN), cancer antigen 125 (CA125), and Wilms tumor 1 (WT1) in both epithelioid and non-epithelioid MPM. All available hematoxylin and eosin-stained slides from patients who were diagnosed with MPM (1989-2010) were reviewed. We constructed tissue microarrays from 283 patients (epithelioid = 234; non-epithelioid = 49). Intensity and distribution for each antigen were assessed by immunohistochemistry. Positive expression of MSLN, CA125, and WT1 were demonstrated in 93%, 75%, and 97% of epithelioid MPM cases, and 57%, 33%, and 98% of non-epithelioid MPM cases, respectively. Triple- and double-positive antigen coexpressions were demonstrated in 72% and 23% of epithelioid MPM cases and 29% and 33% of non-epithelioid MPM cases, respectively. Complete absence of expression for all three antigens was demonstrated in <2% of MPM cases. More than two-thirds of MPM cases had ≥50% distribution of MSLN-positive cells and, among the remaining third, half had ≥50% distribution of WT1-positive cells. CA125/MSLN coexpression was observed in more tha...Continue Reading

References

Dec 17, 2003·The Journal of Biological Chemistry·Armin RumpAtsushi Miyajima
May 28, 2005·Leukemia·U KeilholzH Sugiyama
Aug 2, 2005·Lancet·Bruce W S RobinsonRichard A Lake
Apr 13, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W WederUNKNOWN Swiss Group for Clinical Cancer Research
Apr 1, 2008·The Journal of Thoracic and Cardiovascular Surgery·Masaki AnrakuMarc de Perrot
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lee M KrugNicholas J Vogelzang
May 11, 2010·Applied Immunohistochemistry & Molecular Morphology : AIMM·Thapi Dharma RaoDavid R Spriggs
Jun 8, 2010·The European Respiratory Journal·P E Van SchilUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC) Lung Cancer Group
Jun 23, 2010·Cancer Immunology, Immunotherapy : CII·Noriyuki YamadaMasaharu Nishimura
Mar 2, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kyuichi KadotaWilliam D Travis
Nov 9, 2011·PloS One·Dhanya HaridasSurinder K Batra
Dec 8, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dung T LeDaniel A Laheru
Jan 13, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nabil P RizkPrasad S Adusumilli
Mar 1, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elliot L ServaisPrasad S Adusumilli
Oct 17, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Valerie W RuschUNKNOWN IASLC Staging Committee
Apr 4, 2013·Cancer Discovery·Michel SadelainIsabelle Rivière
May 23, 2013·Scientific Reports·Shih-Hsun ChenKonstantinos Konstantopoulos
Aug 14, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Meenakshi HegdeNabil Ahmed
Dec 18, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stefan S KachalaPrasad S Adusumilli
Mar 29, 2014·The Cancer Journal·Victor D FedorovChristopher C Kloss
Sep 19, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raffit HassanBruce A Wallin
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisAndrew G Nicholson
Nov 23, 2015·Surgery Today·Teruhisa Takuwa, Seiki Hasegawa
Nov 29, 2015·The Journal of Thoracic and Cardiovascular Surgery·Marc de PerrotB C John Cho
Jun 22, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andreas RimnerLee M Krug
Jul 19, 2016·The Journal of Clinical Investigation·Meenakshi HegdeNabil Ahmed

❮ Previous
Next ❯

Citations

Jun 26, 2020·Frontiers in Oncology·Robert A BelderbosJoachim G J V Aerts
May 1, 2021·Biomedicines·Sören WeidemannRonald Simon
Apr 30, 2021·Science Translational Medicine·Axel Hyrenius-WittstenKole T Roybal
Jul 3, 2021·Cancers·Rita TerenzianiMara Bonelli
Aug 24, 2021·Current Treatment Options in Oncology·Elizabeth DudnikLiran Holtzman

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02414269
NCT01583686
NCT02159716
NCT01355965
NCT02930993
NCT02550535
NCT01621724

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Elliot L ServaisPrasad S Adusumilli
Annals of Cardiothoracic Surgery
Christopher CaoRebecca Harris
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
S CedrésE Felip
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
G MaggiE Ruffini
© 2022 Meta ULC. All rights reserved