Cancer-Associated Angiogenesis: The Endothelial Cell as a Checkpoint for Immunological Patrolling.

Cancers
Antonio Giovanni SolimandoDomenico Ribatti

Abstract

Cancer-associated neo vessels' formation acts as a gatekeeper that orchestrates the entrance and egress of patrolling immune cells within the tumor milieu. This is achieved, in part, via the directed chemokines' expression and cell adhesion molecules on the endothelial cell surface that attract and retain circulating leukocytes. The crosstalk between adaptive immune cells and the cancer endothelium is thus essential for tumor immune surveillance and the success of immune-based therapies that harness immune cells to kill tumor cells. This review will focus on the biology of the endothelium and will explore the vascular-specific molecular mediators that control the recruitment, retention, and trafficking of immune cells that are essential for effective antitumor immunity. The literature revision will also explore how abnormalities in the tumor endothelium impair crosstalk with adaptive immune cells and how targeting these abnormalities can improve the success of immune-based therapies for different malignancies, with a particular focus on the paradigmatic example represented by multiple myeloma. We also generated and provide two original bio-informatic analyses, in order to sketch the physiopathology underlying the endothelial-ne...Continue Reading

References

Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P B VermeulenL Y Dirix
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·A W GriffioenG Groenewegen
Mar 13, 2002·General Pharmacology·D RibattiM Presta
Mar 14, 2002·The American Journal of Pathology·Shunichi MorikawaDonald M McDonald
Jun 27, 2002·British Journal of Cancer·J HasanG C Jayson
Jan 17, 2003·Cell Research·Weiming XuIan G Charles
Feb 14, 2003·The New England Journal of Medicine·Jonathan M HillToren Finkel
May 7, 2003·The Journal of Experimental Medicine·Thomas EnzlerGlenn Dranoff
Aug 21, 2003·Cancer Treatment Reviews·Aoife M ShannonDeirdre Toomey
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuan LiuCharles A Parkos
Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
May 27, 2004·The American Journal of Pathology·Carine Michiels
Jun 17, 2004·Journal of Anatomy·Claudio ScavelliDomenico Ribatti
Jan 5, 2005·Journal of Leukocyte Biology·Joan M Cook-Mills, Tracy L Deem
Mar 23, 2005·Mathematical Medicine and Biology : a Journal of the IMA·Alexander R A Anderson
Apr 14, 2006·Neoplasia : an International Journal for Oncology Research·P K Y GoonA D Blann
Jul 20, 2006·Molecular Cancer Research : MCR·Constantinos Koumenis, Bradly G Wouters
Aug 2, 2006·Cancer Letters·Domenico RibattiAngelo Vacca
Sep 23, 2006·Leukemia·D RibattiA Vacca
Oct 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Per Ø SakariassenPer Øyvind Enger
Dec 15, 2006·International Journal of Immunopathology and Pharmacology·V FlatiS Martinotti
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caroline BouzinOlivier Feron
Aug 19, 2007·Trends in Immunology·Silvano SozzaniMarco Presta
Aug 25, 2007·Nature Reviews. Immunology·Klaus LeySussan Nourshargh
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen L ShiaoJordan S Pober
Nov 21, 2007·Nature Immunology·Susan R Schwab, Jason G Cyster
Nov 21, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M Christiane Brahimi-HornJacques Pouysségur
Nov 22, 2007·Expert Opinion on Therapeutic Targets·Steven R BarthelCharles J Dimitroff
Mar 5, 2008·The Journal of Clinical Investigation·Bin ZhangHans Schreiber
May 9, 2008·The New England Journal of Medicine·Robert S Kerbel
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michio TomuraOsami Kanagawa
Nov 28, 2008·British Journal of Haematology·William W LiGerald Gehr
Jun 2, 2009·Seminars in Cancer Biology·Vanessa Baeriswyl, Gerhard Christofori
Jun 13, 2009·Current Molecular Medicine·Sara RockwellVan Thuc Vu
Sep 23, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marcio Nucci, Elias Anaissie
Dec 2, 2009·Cell Adhesion & Migration·Mei Chung Moh, Shali Shen
Jan 28, 2010·Cancer Research·Isabel M PiresEster M Hammond
Feb 19, 2010·Trends in Molecular Medicine·Gwendal Lazennec, Ann Richmond
May 27, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sung-Suk ChaeDai Fukumura

❮ Previous
Next ❯

Citations

Apr 4, 2021·Cancers·Alberto ZanettoPatrizia Burra
May 1, 2021·International Journal of Molecular Sciences·Gustavo Ramos-EspinosaChristian Gorzelanny
May 1, 2021·Cancers·Yang ZhaoJennifer Gamble
Jun 3, 2021·Cancers·Alice BoilèveCindy Neuzillet
Jun 9, 2021·Journal of Experimental & Clinical Cancer Research : CR·Revati SharmaNuzhat Ahmed
Aug 3, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Shidong TanZhongqun Wang
Aug 28, 2021·International Journal of Molecular Sciences·Giuseppe MurdacaSebastiano Gangemi

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE28331

Methods Mentioned

BETA
flow cytometry

Software Mentioned

ggplot2
affy
Factoextra
colorspace
limma
dendextend

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2021 Meta ULC. All rights reserved