Cancer associated fibroblasts as novel promising therapeutic targets in breast cancer.

Pathology, Research and Practice
Sevda SalimifardFarhad Jadidi-Niaragh

Abstract

Breast cancer is one of the most important women-related malignancies, which is incurable (particularly in advanced stages) and tumor microenvironment is a number one accused part in the inefficiency of current anti-breast cancer therapeutic strategies. The tumor microenvironment is composed of various cellular and acellular components, which provide an optimum condition for freely expanding cancer cells in various cancer types, particularly breast cancer. Cancer-associated fibroblasts (CAFs) are one of the main cell types in the breast tumor region, which can promote various tumor-promoting processes such as expansion, angiogenesis, metastasis and drug resistance. CAFs directly (by cell-to-cell communication) and indirectly (through secreting soluble factors) can exert their tumorigenic functions. We try to elucidate the immunobiology of CAFs, their origin, function, and heterogeneity in association with their role in various cancer-promoting processes in breast cancer. Based on current knowledge, we believe that the origin of CAFs, their subsets, and their specific expressed biomarkers determine their pro- or anti-tumor functions. Therefore, targeting CAF without considering their specific functions may lead to a deleterious ...Continue Reading

Citations

Sep 23, 2020·International Journal of Molecular Sciences·Issraa ShoucairCathie Garnis
Jan 6, 2021·Journal of Mammary Gland Biology and Neoplasia·María Belén GiorelloNorma Alejandra Chasseing
Apr 4, 2021·Cancers·Rushikesh S JoshiManish K Aghi
Jul 15, 2021·Oxidative Medicine and Cellular Longevity·J P Jose MerlinKieran Murphy
Jul 9, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Catarina Nascimento, Fernando Ferreira

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