Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology

Human Reproduction Update
Sun-Wei Guo

Abstract

Endometriosis is a benign gynaecological disease. Thus, it came as a complete surprise when it was reported recently that the majority of deep endometriosis lesions harbour somatic mutations and a sizeable portion of them contain known cancer-associated mutations (CAMs). Four more studies have since been published, all demonstrating the existence of CAMs in different subtypes of endometriosis. While the field is still evolving, the confirmation of CAMs has raised many questions that were previously overlooked. A comprehensive overview of CAMs in endometriosis has been produced. In addition, with the recently emerged understanding of the natural history of endometriotic lesions as well as CAMs in normal and apparently healthy tissues, this review attempts to address the following questions: Why has there been such a wild discrepancy in reported mutation frequencies? Why does ectopic endometrium have a higher mutation rate than that of eutopic endometrium? Would the presence of CAMs in endometriotic lesions increase the risk of cancer to the bearers? Why do endometriotic epithelial cells have much higher mutation frequencies than their stromal counterpart? What clinical implications, if any, do the CAMs have for the bearers? Do t...Continue Reading

References

Oct 1, 1976·Science·P C Nowell
Oct 12, 1976·Biochimica Et Biophysica Acta·P J Fialkow
Jul 1, 1992·Acta Obstetricia Et Gynecologica Scandinavica·M H Moen, T B Halvorsen
Sep 1, 1996·Molecular Endocrinology·M H Barcellos-Hoff, T A Dix
Feb 1, 1997·American Journal of Obstetrics and Gynecology·I A Brosens
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·M D Maines
Apr 16, 1999·American Journal of Obstetrics and Gynecology·Y KosugiF Z Bischoff
Jul 28, 1999·Molecular Human Reproduction·J FujimotoT Tamaya
Oct 8, 1999·Immunity·E Gilboa
Oct 12, 1999·American Journal of Reproductive Immunology : AJRI·M TamuraA Yajima
Jun 28, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D VinatierP Dufour
Apr 11, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R C SternS J Robboy
Oct 29, 2002·International Journal of Cancer. Journal International Du Cancer·Maurizio MartiniLuigi Maria Larocca
Dec 12, 2002·Steroids·Deborah A Lannigan
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marcus S CookeJoseph Lunec
Jul 2, 2003·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M S AbraoJ A Pinotti
Aug 5, 2003·The Journal of Biological Chemistry·Mark GagliardiPierre-Andre Bedard
Nov 13, 2003·Molecular and Cellular Biology·Cesare PatroneMagnus Nord
Jan 17, 2004·International Journal of Colorectal Disease·Brit FitznerRobert Jaster
Apr 28, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Mark D Evans, Marcus S Cooke
Jun 16, 2004·Nuclear Receptor·Linda Björnström, Maria Sjöberg
Jul 9, 2004·JAMA : the Journal of the American Medical Association·Hugh S Taylor
Aug 25, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S AmemiyaT Okai
Feb 22, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Witold W KilarskiPär Gerwins
Jun 21, 2005·Annals of the New York Academy of Sciences·Shu-Huei KaoChii-Reuy Tzeng
Sep 17, 2005·Cancer Research·David J AratenLucio Luzzatto
Nov 18, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L BenoitJ Cuisenier
Feb 16, 2006·Journal of the National Cancer Institute·Jérôme AlexandreFrédéric Batteux
May 9, 2006·Gynecologic and Obstetric Investigation·Yan WuSun-Wei Guo
Jul 1, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Rouba Ali-FehmiAdnan R Munkarah
Sep 22, 2006·Antioxidants & Redox Signaling·James A McCubreyRichard A Franklin

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Citations

Jun 20, 2020·Human Reproduction Update·Sun-Wei Guo
Jun 20, 2020·Human Reproduction Update·Zeev Blumenfeld
Jun 24, 2020·Journal of Clinical Medicine·Lutz KonradIvo Meinhold-Heerlein
Oct 20, 2020·Reproductive Medicine and Biology·Tetsuya HirataYutaka Osuga
Sep 27, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Philippe R KoninckxDan C Martin
Jul 28, 2020·Reproductive Biomedicine Online·Dingmin YanSun-Wei Guo
Mar 27, 2021·Seminars in Cancer Biology·Khalid El BairiSaid Afqir
Aug 20, 2020·The Journal of Clinical Endocrinology and Metabolism·Dingmin YanSun-Wei Guo
Mar 31, 2021·Virchows Archiv : an International Journal of Pathology·Andrew H S LeePuay Hoon Tan
May 20, 2021·Minerva Obstetrics and Gynecology·Flavia SorbiFelice Petraglia
May 29, 2021·Cell·Philippa T K Saunders, Andrew W Horne
Jun 10, 2021·International Journal of Women's Health·Lyudmila M MikhalevaMikhail Y Sinelnikov
Sep 14, 2021·Reproductive Sciences·Ramanaiah MamillapalliHugh S Taylor
Nov 3, 2021·Archives of Gynecology and Obstetrics·Leyi NiCong Chen

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