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Cancer-associated recurrent mutations in RNase III domains of DICER1

bioRxiv

May 29, 2014

Bülent Arman AksoyChris Sander

Abstract

Mutations in the RNase IIIb domain of DICER1 are known to disrupt processing of 5p-strand pre-miRNAs and these mutations have previously been associated with cancer. Using data from the Cancer Genome Atlas project, we show that these mutations are recurrent across four cancer types and ...read more

Mentioned in this Paper

Imbalance
Adjacent
Transcriptional Activation Domain
Transcript
Production of miRNAs Involved in Gene Silencing by miRNA
Nucleic Acid Strand
Mutation Abnormality
Pancreatic ribonuclease
Ribonucleases
RNA, Messenger
18
10
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Cancer-associated recurrent mutations in RNase III domains of DICER1

bioRxiv

May 29, 2014

Bülent Arman AksoyChris Sander

PMID: 990005686

DOI: 10.1101/005686

Abstract

Mutations in the RNase IIIb domain of DICER1 are known to disrupt processing of 5p-strand pre-miRNAs and these mutations have previously been associated with cancer. Using data from the Cancer Genome Atlas project, we show that these mutations are recurrent across four cancer types and ...read more

Mentioned in this Paper

Imbalance
Adjacent
Transcriptional Activation Domain
Transcript
Production of miRNAs Involved in Gene Silencing by miRNA
Nucleic Acid Strand
Mutation Abnormality
Pancreatic ribonuclease
Ribonucleases
RNA, Messenger
18
10

Similar Papers Found In These Feeds

Paper Details
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