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Cancer-associated recurrent mutations in RNase III domains of DICER1

bioRxiv

May 29, 2014

Bülent Arman AksoyChris Sander

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Abstract

Mutations in the RNase IIIb domain of DICER1 are known to disrupt processing of 5p-strand pre-miRNAs and these mutations have previously been associated with cancer. Using data from the Cancer Genome Atlas project, we show that these mutations are recurrent across four cancer types and ...read more

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Production of miRNAs Involved in Gene Silencing by miRNA
Pancreatic ribonuclease
Mutation Abnormality
Neoplastic Cell Transformation
Imbalance
Genome
Endoribonucleases
MicroRNAs
Ribonucleases
DICER1 gene
19
10
Paper Details
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  • Cancer-associated recurrent mutations in RNase III domains of DICER1

    bioRxiv

    May 29, 2014

    Bülent Arman AksoyChris Sander

    PMID: 990005686

    DOI: 10.1101/005686

    Abstract

    Mutations in the RNase IIIb domain of DICER1 are known to disrupt processing of 5p-strand pre-miRNAs and these mutations have previously been associated with cancer. Using data from the Cancer Genome Atlas project, we show that these mutations are recurrent across four cancer types and ...read more

    Mentioned in this Paper

    Production of miRNAs Involved in Gene Silencing by miRNA
    Pancreatic ribonuclease
    Mutation Abnormality
    Neoplastic Cell Transformation
    Imbalance
    19
    10
    Paper Details
    References
    • References
    • Citations

      References currently unavailable

      We're still populating references for this paper, please check back later.
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