Cancer-associated thrombosis: investigating the role of new oral anticoagulants

Thrombosis Research
Massimo FranchiniGiuseppe Lippi

Abstract

Venous thromboembolism (VTE) is a common complication of cancer and has a significant impact on morbidity and mortality in patients with malignancies. Low molecular weight heparins (LMWHs) currently represent the drug of choice for both initial and long-term treatment of cancer-associated thrombosis. In recent years, however, a new class of novel oral anticoagulants (NOACs) inhibiting directly thrombin or activated factor X have been proposed as an alternative therapeutic option on the basis the results of subgroup analyses of phase III randomized controlled trials, including few cases of patients with cancer. After analysis of the available literature data, we conclude that although potentially interesting, future research specifically conducted in cancer patients is needed to clarify the role of these newer anticoagulant agents in prevention and treatment of cancer-related VTE.

References

Dec 16, 2000·The New England Journal of Medicine·H T SørensenJ A Baron
Jun 1, 2002·Archives of Internal Medicine·John A HeitL Joseph Melton
Mar 8, 2005·Journal of Thrombosis and Haemostasis : JTH·E PerzbornA Straub
Mar 1, 2006·Archives of Internal Medicine·Helen K ChewRichard H White
Feb 27, 2007·Journal of Thrombosis and Haemostasis : JTH·A A KhoranaG H Lyman
Oct 4, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Nirmala RaghavanDonglu Zhang
Sep 29, 2009·European Journal of Internal Medicine·Massimo Franchini, Pier Mannuccio Mannucci
Dec 8, 2009·The New England Journal of Medicine·Sam SchulmanUNKNOWN RE-COVER Study Group
Dec 7, 2010·The New England Journal of Medicine·Rupert BauersachsSebastian Schellong
Nov 15, 2011·The New England Journal of Medicine·Samuel Z GoldhaberUNKNOWN ADOPT Trial Investigators
Mar 14, 2012·Journal of Thrombosis and Haemostasis : JTH·M N LevineJ Julian
Mar 28, 2012·The New England Journal of Medicine·Harry R BüllerAnnelise Segers
Oct 26, 2012·European Journal of Internal Medicine·Massimo Franchini, Pier Mannuccio Mannucci
Feb 8, 2013·The New England Journal of Medicine·Alexander T CohenUNKNOWN MAGELLAN Investigators
Feb 22, 2013·The New England Journal of Medicine·Sam SchulmanUNKNOWN RE-SONATE Trial Investigators
Mar 15, 2013·Thrombosis Research·Sam Schulman
May 15, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary H LymanUNKNOWN American Society of Clinical Oncology Clinical Practice
May 17, 2013·The New England Journal of Medicine·Alexander T CohenUNKNOWN MAGELLAN Steering Committee
Jul 3, 2013·The New England Journal of Medicine·Giancarlo AgnelliUNKNOWN AMPLIFY Investigators
Jul 12, 2013·Blood·Agnes Y Y Lee, Erica A Peterson
Sep 3, 2013·The New England Journal of Medicine·Harry R BüllerPhil Wells
Dec 18, 2013·Circulation·Sam SchulmanUNKNOWN RE-COVER II Trial Investigators
May 8, 2014·American Journal of Therapeutics·Partha SardarWilbert S Aronow
Jul 19, 2014·Drugs·Henri Bounameaux, A John Camm

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Citations

Jul 7, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Trisha A RettigSherry D Fleming
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B SousaUNKNOWN ESMO Guidelines Committee
Jul 6, 2016·Journal of Asian Natural Products Research·Bao-Zhan HuangWen Huang
Jun 18, 2017·Radiation and Environmental Biophysics·Tolebay RakhypbekovMadina Madiyeva
Nov 22, 2017·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Jessie R Signorelli, Arpita S Gandhi
Sep 2, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Massimo Franchini, Pier Mannuccio Mannucci
Mar 2, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Laura PakTolebay Rakhypbekov
Mar 13, 2016·Journal of Neuro-oncology·Yong-Won ShinSang Kun Lee
Oct 21, 2017·Journal of Thrombosis and Thrombolysis·Elaine XiangJohn Papadopoulos
Oct 27, 2018·World Journal of Gastrointestinal Oncology·Aikaterini MastorakiNikolaos Arkadopoulos
Jul 29, 2017·European Heart Journal Supplements : Journal of the European Society of Cardiology·Iolanda EneaMarino Scherillo
Sep 1, 2021·Seminars in Thrombosis and Hemostasis·Massimo FranchiniAntonio Coppola

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