Cancer biomarker discovery for precision medicine: new progresses

Current Medicinal Chemistry
Jinfeng Zou, Edwin Wang

Abstract

Precision medicine puts forward customized healthcare for cancer patients. An important way to accomplish this task is to stratify patients into those who may respond to a treatment and those who may not. For this purpose, diagnostic and prognostic biomarkers have been pursued. This review focuses on novel approaches and concepts of exploring biomarker discovery under the circumstances that technologies are developed, and data are accumulated for precision medicine. The traditional mechanism-driven functional biomarkers have the advantage of actionable insights, while data-driven computational biomarkers can fulfill more needs, especially with tremendous data on the molecules of different layers (e.g. genetic mutation, mRNA, protein etc.) which are accumulated based on a plenty of technologies. Besides, the technology-driven liquid biopsy biomarker is very promising to improve patients' survival. The developments of biomarker discovery on these aspects are promoting the understanding of cancer, helping the stratification of patients and improving patients' survival. Current developments on mechanisms-, data- and technology-driven biomarker discovery are achieving the aim of precision medicine and promoting the clinical applicat...Continue Reading

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Citations

Jan 17, 2020·Current Medicinal Chemistry·Zunnan Huang, Ruo-Xu Gu
May 24, 2021·Cancer Cell International·Menggang ZhangWenzhi Guo
Oct 1, 2021·The Journal of International Medical Research·Shasha LiuXingbin Shen
Jan 25, 2022·Journal of Cellular and Molecular Medicine·Ying LiuShouxiang Kuang

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