Cancer cachexia and anabolic interventions: a case report.

Journal of Cachexia, Sarcopenia and Muscle
Edgar L DillonMelinda Sheffield-Moore

Abstract

Standard-of-care (SOC) cancer treatments are primarily aimed at reducing size and progression of a tumor. There is a need for successful supplemental anabolic therapies to combat cancer cachexia in addition to these SOC treatment modalities. Anabolic interventions, including testosterone and amino acid supplements, may be beneficial in reducing and/or reversing muscle wasting in these patient populations. A 48-year-old Caucasian female with recurrent cervical cancer was scheduled to receive three 21-day cycles of cisplatin and topetecan chemotherapy. She qualified, consented, and enrolled into a blinded interventional pilot study where she received daily whey protein (10 g, three times per day with meals) and a weekly injection of testosterone enanthate (100 mg intramuscular) before and during the SOC chemotherapy treatment period. Body composition, serum inflammatory markers, mixed muscle protein synthesis and breakdown rates, physical function, fatigue, and quality of life were assessed before and after the intervention period. Body composition, as assessed by an increase in body weight and lean body mass and reduction in fat mass; physical function; fatigue; and quality of life each improved across the entire intervention pe...Continue Reading

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Citations

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Methods Mentioned

BETA
biopsy
X-ray
blood draws
ELISA
biopsies

Clinical Trials Mentioned

NCT00878995

Software Mentioned

MOS
Biodex
Lunar
Biodex Advantage
FACT

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