Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia.

Journal of Cachexia, Sarcopenia and Muscle
Sara Peixoto da SilvaRui Medeiros

Abstract

Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal muscle mass, along with adipose tissue wasting, systemic inflammation and other metabolic abnormalities leading to functional impairment. Cancer cachexia has long been recognized as a direct cause of complications in cancer patients, reducing quality of life and worsening disease outcomes. Some related conditions, like sarcopenia (age-related muscle wasting), anorexia (appetite loss) and asthenia (reduced muscular strength and fatigue), share some key features with cancer cachexia, such as weakness and systemic inflammation. Understanding the interplay and the differences between these conditions is critical to advance basic and translational research in this field, improving the accuracy of diagnosis and contributing to finally achieve effective therapies for affected patients.

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Citations

Apr 25, 2020·Cancers·Joana M O SantosRui Medeiros
Jul 28, 2020·International Journal of Molecular Sciences·Sara Peixoto da SilvaRui Medeiros
Sep 23, 2020·Nutrición hospitalaria·Vanusa Felício de SouzaValdete Regina Guandalini
Aug 23, 2020·International Journal of Molecular Sciences·Cecilia T de BarrosMarco V Chaud
Jan 1, 2021·Journal of Cachexia, Sarcopenia and Muscle·Carla M PradoStephan von Haehling
Jan 26, 2021·Expert Opinion on Pharmacotherapy·Guilherme Wesley Peixoto Da Fonseca, Stephan von Haehling
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Aug 28, 2021·Life·Julia Windi GunadiRonny Lesmana

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