Cancer Cell Membrane Camouflaged Nanoparticles to Realize Starvation Therapy Together with Checkpoint Blockades for Enhancing Cancer Therapy

ACS Nano
Wei XieWei Liu

Abstract

Although anti-PD-1 immunotherapy is widely used to treat melanoma, its efficacy still has to be improved. In this work, we present a therapeutic method that combines immunotherapy and starvation therapy to achieve better antitumor efficacy. We designed the CMSN-GOx method, in which mesoporous silica nanoparticles (MSN) are loaded with glucose oxidase (GOx) and then encapsulate the surfaces of cancer cell membranes to realize starvation therapy. By functionalizing the MSN's biomimetic surfaces, we can synthesize nanoparticles that can escape the host immune system and homologous target. These attributes enable the nanoparticles to have improved cancer targeting ability and enrichment in tumor tissues. Our synthetic CMSN-GOx complex can ablate tumors and induce dendritic cell maturity to stimulate an antitumor immune response. We performed an in vivo analysis of these nanoparticles and determined that our combined therapy CMSN-GOx plus PD-1 exhibits a better antitumor therapeutic effect than therapies using CMSN-GOx or PD-1 alone. Additionally, we used the positron emission tomography imaging to measuring the level of glucose metabolism in tumor tissues, for which we investigate the effect with the cancer therapy in vivo.

References

Jan 28, 1994·Cell·C A Janeway, K Bottomly
Mar 5, 2003·Annual Review of Immunology·Drew Pardoll
Jul 1, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Weibo Cai, Xiaoyuan Chen
Nov 17, 2009·Advanced Drug Delivery Reviews·Sarit S AgastiVincent M Rotello
Dec 18, 2009·Endocrinology·Banu S ZolnikMarina A Dobrovolskaia
Apr 13, 2013·Current Opinion in Immunology·Thomas F GajewskiStefani Spranger
Jan 31, 2015·Accounts of Chemical Research·Xiaolian SunXiaoyuan Chen
Mar 13, 2015·Nature·Rachel Lubong Sabado, Nina Bhardwaj
Apr 4, 2015·Science·Padmanee Sharma, James P Allison
Apr 11, 2015·Cancer Cell·Suzanne L TopalianDrew M Pardoll
Apr 22, 2015·The New England Journal of Medicine·Caroline RobertUNKNOWN KEYNOTE-006 investigators
Jun 2, 2015·The New England Journal of Medicine·James LarkinJedd D Wolchok
Jun 28, 2015·Diabetes Care·Mahnaz MellatiIrl B Hirsch
Sep 16, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J NaidooJ D Wolchok
Nov 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Laura Jeanbart, Melody A Swartz
Dec 8, 2015·Nano Today·Alexander S Cheung, David J Mooney
Jan 21, 2016·Nature Reviews. Clinical Oncology·Elizabeth I Buchbinder, F Stephen Hodi
Feb 21, 2016·Current Opinion in Biotechnology·Sandeep T Koshy, David J Mooney
Mar 13, 2016·Advanced Materials·Lang RaoXing-Zhong Zhao
Apr 17, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Priti S HegdeStefan Evers
Aug 27, 2017·Nature Communications·Minfeng HuoJianlin Shi

❮ Previous
Next ❯

Citations

Nov 27, 2019·Cancers·Jenna C HarrisEmily S Day
Jan 1, 2020·Chembiochem : a European Journal of Chemical Biology·Xing Qin, Yongsheng Li
May 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Long WuWenfei Dong
May 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Daoming ZhuKaiyang Li
Jul 31, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yong WangJie He
Jul 7, 2020·Frontiers in Bioengineering and Biotechnology·Manuela SushnithaFrancesca Taraballi
Oct 4, 2020·IET Nanobiotechnology·Hasnat Tariq, Syed Ali Imran Bokhari
Apr 17, 2020·Angewandte Chemie·Shuangqian YanXiaogang Liu
Oct 6, 2020·Frontiers in Bioengineering and Biotechnology·Chunyu HuangYang Li
Apr 17, 2020·Frontiers in Chemistry·Chunyu HuangQinqin Huang
Apr 3, 2020·International Journal of Molecular Sciences·Vera PetrovaViktor Umansky
Oct 6, 2020·Advanced Biosystems·Järvi M Spanjers, Brigitte Städler
Nov 24, 2020·Chemical Society Reviews·Guo-Feng LuoXian-Zheng Zhang
Feb 1, 2020·Acta Biomaterialia·Cheng-Hui XuCui-Yun Yu
Dec 9, 2020·Advanced Materials·Mengyu ChangJun Lin
Feb 16, 2021·Advanced Healthcare Materials·Faisal RazaQiu Mingfeng
Apr 8, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yuqian ZhangYang Li
May 20, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Liang Ee LowDaishun Ling
Apr 27, 2021·ACS Nano·Qiuhong ZhangYanli Zhao
May 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·V MoralesR A García-Muñoz
Jun 22, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jinzhi XuTong Zhang
Aug 11, 2021·Pharmaceutics·Elham RastegariYueh Chien

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.