Cancer cell metabolism: there is no ROS for the weary

Cancer Discovery
Chi V Dang

Abstract

Using a high-throughput short-hairpin RNA library screen targeting 222 metabolic nodes, Ros and colleagues identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), a glycolytic enzyme that shunts glucose into the pentose phosphate pathway for NADPH production, as a critical node for the survival of prostate cancer cells. Blocking PFKFB4 induces reactive oxygen species and cancer cell death, suggesting that PFKFB4 could be therapeutically targeted.

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Citations

Apr 22, 2015·Critical Reviews in Biochemistry and Molecular Biology·Karina N Gonzalez HerreraMarcia C Haigis
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Mar 29, 2021·Life Sciences·Longzhou ZhangLingchang Kong
Oct 2, 2021·Journal of Experimental & Clinical Cancer Research : CR·Chenchen FengHui Wen

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Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.