Dec 3, 2016

Cancer cell motility: lessons from migration in confined spaces

Nature Reviews. Cancer
Colin D PaulKonstantinos Konstantopoulos


Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has demonstrated the importance of tumour cell migration through confining tracks in vivo. These tracks may either be endogenous features of tissues or be created by tumour or tumour-associated cells. Importantly, migration mechanisms through confining microenvironments are not predicted by 2D migration assays. Engineered in vitro models have been used to delineate the mechanisms of cell motility through confining spaces encountered in vivo. Understanding cancer cell locomotion through physiologically relevant confining tracks could be useful in developing therapeutic strategies to combat metastasis.

Mentioned in this Paper

In Vivo
Cancer Microenvironment
Cell Motility
Tumor Lysis Syndrome
Unventilated Spaces
G25K GTP-Binding Protein, Placental Isoform
Cell Division Phases
Intravital Microscopy

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.