Dec 3, 2016

Cancer cell motility: lessons from migration in confined spaces

Nature Reviews. Cancer
Colin D PaulKonstantinos Konstantopoulos

Abstract

Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has demonstrated the importance of tumour cell migration through confining tracks in vivo. These tracks may either be endogenous features of tissues or be created by tumour or tumour-associated cells. Importantly, migration mechanisms through confining microenvironments are not predicted by 2D migration assays. Engineered in vitro models have been used to delineate the mechanisms of cell motility through confining spaces encountered in vivo. Understanding cancer cell locomotion through physiologically relevant confining tracks could be useful in developing therapeutic strategies to combat metastasis.

Mentioned in this Paper

In Vivo
Cancer Microenvironment
Cell Motility
Neoplasms
Tumor Lysis Syndrome
Unventilated Spaces
G25K GTP-Binding Protein, Placental Isoform
Cell Division Phases
Intravital Microscopy
Fibroblasts

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