Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma.

Cancer Research
Sandro JubeHaining Yang

Abstract

Human malignant mesothelioma is an aggressive and highly lethal cancer that is believed to be caused by chronic exposure to asbestos and erionite. Prognosis for this cancer is generally poor because of late-stage diagnosis and resistance to current conventional therapies. The damage-associated molecular pattern protein HMGB1 has been implicated previously in transformation of mesothelial cells. Here we show that HMGB1 establishes an autocrine circuit in malignant mesothelioma cells that influences their proliferation and survival. Malignant mesothelioma cells strongly expressed HMGB1 and secreted it at high levels in vitro. Accordingly, HMGB1 levels in malignant mesothelioma patient sera were higher than that found in healthy individuals. The motility, survival, and anchorage-independent growth of HMGB1-secreting malignant mesothelioma cells was inhibited in vitro by treatment with monoclonal antibodies directed against HMGB1 or against the receptor for advanced glycation end products, a putative HMGB1 receptor. HMGB1 inhibition in vivo reduced the growth of malignant mesothelioma xenografts in severe-combined immunodeficient mice and extended host survival. Taken together, our findings indicate that malignant mesothelioma cell...Continue Reading

References

Aug 3, 2000·Experimental Lung Research·S TanakaE Kagan
Aug 22, 2000·The Journal of Experimental Medicine·U AnderssonK J Tracey
Aug 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·M BocchettaM Carbone
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E AbrahamK J Tracey
Dec 9, 2003·The Journal of Biological Chemistry·Jong Sung ParkEdward Abraham
Jan 28, 2004·The Journal of Cell Biology·Roberta PalumboMarco E Bianchi
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Davorka MessmerNicholas Chiorazzi
Aug 18, 2004·Biochemical Pharmacology·Roberta Palumbo, Marco E Bianchi
Apr 2, 2005·Nature Reviews. Immunology·Michael T Lotze, Kevin J Tracey
Nov 12, 2005·American Journal of Physiology. Cell Physiology·Shiguang LiuMitchell P Fink
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefania MitolaMarco Presta
Jun 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Haining YangMichele Carbone
Aug 29, 2006·Journal of Leukocyte Biology·Giovanni SitiaLuca G Guidotti
Sep 19, 2006·Journal of Leukocyte Biology·Heidi WähämaaHelena Erlandsson Harris
Oct 13, 2006·Journal of Leukocyte Biology·Marco E Bianchi
Jan 26, 2007·Nature Reviews. Cancer·Michele CarboneY Izzettin Baris
Jan 29, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pietro BertinoGiovanni Gaudino
Jan 30, 2008·Nature Clinical Practice. Oncology·Dean A FennellJan van Meerbeeck
Aug 19, 2008·Current Treatment Options in Oncology·Haining YangMichele Carbone
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Haining YangMichele Carbone
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 18, 2011·Journal of Cellular Physiology·Michele CarboneHaining Yang
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Michele CarboneAubrey Miller
Aug 30, 2011·Nature Genetics·Joseph R TestaMichele Carbone
Nov 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michele Carbone, Haining Yang
Mar 1, 2012·The Journal of Experimental Medicine·Milena SchiraldiMariagrazia Uguccioni

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Citations

Dec 10, 2013·Cell Death and Differentiation·M E Bianchi
May 21, 2013·Cell Death and Differentiation·A D GargP Agostinis
Jun 26, 2013·Immunology and Cell Biology·Kerrilyn R DienerJohn D Hayball
Oct 9, 2013·Immunology and Cell Biology·Monica Escamilla-TilchErnesto Antonio Vázquez-Sánchez
Apr 4, 2013·Nature Reviews. Cancer·Michele CarboneGiovanni Gaudino
Aug 8, 2012·The Journal of Experimental Medicine·Emilie VenereauMarco E Bianchi
Jun 15, 2013·Prostate Cancer·Munirathinam GnanasekarAndré Kajdacsy-Balla
Aug 16, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zeyana RiveraMichele Carbone
Feb 5, 2013·Antioxidants & Redox Signaling·Patrizia CastellaniAnna Rubartelli
Apr 11, 2014·Hormones & Cancer·Madhuwanti SrinivasanGnanasekar Munirathinam
Mar 14, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Isabelle OpitzUNKNOWN ESTS Biology Club
Nov 16, 2012·Nature Reviews. Cancer·Dmitri V KryskoPeter Vandenabeele
May 21, 2013·Journal of Clinical Gastroenterology·Chiharu TabataTakashi Nakano
Aug 27, 2015·Expert Review of Respiratory Medicine·Angela BononiMichele Carbone
Dec 5, 2012·Molecular Immunology·Emilie VenereauMarco E Bianchi
Nov 3, 2012·Trends in Immunology·Hideyuki YanaiTadatsugu Taniguchi
Jul 29, 2016·Oncoimmunology·Lucia CottoneAngelo A Manfredi
Dec 5, 2015·Frontiers in Immunology·Abhishek D GargPatrizia Agostinis
Oct 24, 2015·Antioxidants & Redox Signaling·Vikramjeet SinghArthur Liesz
Jul 27, 2015·Autoimmunity Reviews·Chen WangCees G M Kallenberg
Aug 21, 2013·Journal of Cellular Biochemistry·Joyce K ThompsonArti Shukla
Nov 1, 2013·International Journal of Cancer. Journal International Du Cancer·Fabrizio MarcucciAngelo Corti
Sep 13, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hui LiuWei Wang
Mar 30, 2016·Clinical Therapeutics·Franco PandolfiPio Conti
Jun 24, 2015·Journal of Cellular and Molecular Medicine·Lingyin ZhuXiaobo Li
Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Xing-Jiang MaoHui-Ling Wang
May 16, 2015·Free Radical Biology & Medicine·Shan Hwu Chew, Shinya Toyokuni
Jun 27, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wenna ShiBaoquan Cheng
Apr 23, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shibing GuoWenxuan Wang
Jul 11, 2014·Molecular Aspects of Medicine·Rui KangDaolin Tang
Oct 30, 2012·Biochimica Et Biophysica Acta·Guglielmo SorciRosario Donato
Apr 19, 2016·Oncogene·C HernandezR F Schwabe
Feb 5, 2014·Biochimica Et Biophysica Acta·Leonardo Vinícius Monteiro de AssisMauro César Isoldi
Jan 27, 2015·Annual Review of Immunology·Seng-Ryong WooThomas F Gajewski
Jan 13, 2015·Experimental and Therapeutic Medicine·Xin-Jun WangJian Ma
Jan 8, 2015·Frontiers in Immunology·Lauri JouhiJaana Hagström

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