Cancer cell transmission via the placenta

Evolution, Medicine, and Public Health
Mel Greaves, William Hughes

Abstract

Cancer cells have a parasitic propensity in the primary host but their capacity to transit between individuals is severely restrained by two factors: a lack of a route for viable cell transfer and immune recognition in allogeneic, secondary recipients. Several examples of transmissible animal cancers are now recognised. In humans, the only natural route for transmission is via the haemochorial placenta which is permissive for cell traffic. There are three special examples of this occurring in utero: maternal to foetus, intraplacental twin to twin leukaemias and choriocarcinoma-extra-embryonic cells to mother. We discuss the rare circumstances under which such transmission occurs.

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Citations

Nov 8, 2019·Blood·Margarete A FabreGeorge S Vassiliou
Jun 7, 2019·PLoS Biology·Frédéric ThomasBeata Ujvari
Nov 20, 2020·PLoS Biology·Thomas G AubierHanna Kokko
Jan 7, 2021·The New England Journal of Medicine·Ayumu ArakawaChitose Ogawa
Dec 20, 2020·Cancers·Dominik Franciszek DłuskiBożena Leszczyńska-Gorzelak
May 8, 2021·Placenta·Peeyush K LalaChidambra Halari
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F AmantI Zapardiel
Dec 29, 2021·Immunological Medicine·Rafael Cardoso Maciel Costa SilvaBruno Ricardo Barreto Pires

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