Cancer Cells Exploit Notch Signaling to Redefine a Supportive Cytokine Milieu

Frontiers in Immunology
Michela ColomboNatalia Platonova

Abstract

Notch signaling is a well-known key player in the communication between adjacent cells during organ development, when it controls several processes involved in cell differentiation. Notch-mediated communication may occur through the interaction of Notch receptors with ligands on adjacent cells or by a paracrine/endocrine fashion, through soluble molecules that can mediate the communication between cells at distant sites. Dysregulation of Notch pathway causes a number of disorders, including cancer. Notch hyperactivation may be caused by mutations of Notch-related genes, dysregulated upstream pathways, or microenvironment signals. Cancer cells may exploit this aberrant signaling to "educate" the surrounding microenvironment cells toward a pro-tumoral behavior. This may occur because of key cytokines secreted by tumor cells or it may involve the microenvironment through the activation of Notch signaling in stromal cells, an event mediated by a direct cell-to-cell contact and resulting in the increased secretion of several pro-tumorigenic cytokines. Up to now, review articles were mainly focused on Notch contribution in a specific tumor context or immune cell populations. Here, we provide a comprehensive overview on the outcomes o...Continue Reading

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Citations

Jul 4, 2019·International Journal of Molecular Sciences·Michela ColomboRaffaella Chiaramonte
Jan 20, 2019·International Journal of Molecular Sciences·Raffaella MarconiLidia Strigari
Apr 25, 2020·World Journal of Gastroenterology : WJG·Mihaela Chivu-EconomescuCarmen Cristina Diaconu
Mar 7, 2020·Leukemia·Keenan T HartertAnne J Novak
Oct 11, 2019·The Journal of Biological Chemistry·Carlo De BlasioClaudio Talora
Jun 25, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johann S BergholzJean J Zhao
Apr 15, 2021·Progress in Retinal and Eye Research·Thomas StrubCorine Bertolotto
Apr 20, 2021·Genes & Development·Ajeya Nandi, Rumela Chakrabarti
Jun 3, 2021·International Journal of Molecular Sciences·Can HuangPatricia Santofimia-Castaño
Aug 24, 2021·Frontiers in Cell and Developmental Biology·Pankaj TrivediMaria Pia Felli
Nov 23, 2021·Frontiers in Physiology·Hyun Jun JungPaul A Welling
Oct 30, 2021·International Journal of Stem Cells·Jin Woo Lee, Hwa-Yong Lee

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Methods Mentioned

BETA
transgenic
xenograft
xenografts
dissection

Clinical Trials Mentioned

NCT02452008
NCT02423343
NCT01246986
NCT01373164
NCT00433446
NCT00385827
NCT00311545
NCT03135171
NCT00401843
NCT01531998

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