Cancer cells govern miR-2909 exosomal recruitment through its 3'-end post-transcriptional modification

Cell Biochemistry and Function
Sameena Wani, Deepak Kaul

Abstract

It is widely believed that selective packaging of nucleic acids, especially microRNAs, into exosomes secreted by the cancer cells not only ensures their growth and survival but also helps in the escape from immune surveillance. Keeping in view the fact that human cellular miR-2909 has emerged to regulate genes involved in oncogenesis and immunity, the present study was addressed to reveal the nature of miR-2909 expression within cancer cells of different tissue origin and its incorporation into exosomes secreted by these cells. Post-transcriptional modification, especially 3'-end adenylation and uridylation of miR-2909, exerts opposing effects that may contribute to direct its sorting into exosomes secreted by cancer cells. Our study also revealed that selective partitioning of adenosine kinase, between cancer cells and their secreted exosomes, may be responsible for the nature of post-transcriptional modification of miR-2909 observed within these cells.

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Citations

May 17, 2019·Science Translational Medicine·Oscar P B WiklanderSamir El Andaloussi
Jul 24, 2020·International Journal of Cancer. Journal International Du Cancer·Tamar Barenholz-CohenDaphne Weihs
Apr 18, 2019·International Journal of Molecular Sciences·Stefania RaimondoRiccardo Alessandro
Oct 8, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sameena WaniCharalabos Pothoulakis
Jan 8, 2021·Aging·Mario Morales-MartinezMario I Vega
Apr 13, 2021·Frontiers in Molecular Biosciences·Marta TapparoGiovanni Camussi

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