Cancer cells optimize elasticity for efficient migration

Royal Society Open Science
Ahmad Sohrabi Kashani, Muthukumaran Packirisamy

Abstract

Cancer progression is associated with alternations in the cytoskeletal architecture of cells and, consequently, their mechanical properties such as stiffness. Changing the mechanics of cells enables cancer cells to migrate and invade to distant organ sites. This process, metastasis, is the main reason for cancer-related mortality. Cell migration is an essential step towards increasing the invasive potential of cells. Although many studies have shown that the migratory speed and the invasion of cells can be inversely correlated to the stiffness of cells, some other investigations indicate opposing results. In the current work, based on the strain energy stored in cells due to the contractile forces, we defined an energy-dependent term, migratory index, to approximate how changes in the mechanical properties of cells influence cell migration required for cancer progression. Cell migration involves both cell deformation and force transmission within cells. The effects of these two parameters can be represented equally by the migratory index. Our mechanical modelling and computational study show that cells depending on their shape, size and other physical parameters have a maximum migratory index taking place at a specific range of...Continue Reading

Associated Datasets

Oct 2, 2020·Muthukumaran Packirisamy, Ahmad Sohrabi Kashani

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Methods Mentioned

BETA
atomic force microscopy
AFM

Software Mentioned

COMSOL
COMSOL Multiphysics

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