Cancer chemoprevention locks onto a new polyamine metabolic target.

Cancer Prevention Research
E W Gerner

Abstract

Ornithine decarboxylase has a relatively long history as a target for cancer chemoprevention and chemotherapy. Plym Forshell et al. report new evidence (beginning on p. 140 in this issue of the journal) indicating that spermidine synthase, a fellow enzyme of ornithine decarboxylase in polyamine metabolism, is transactivated in part by the MYC gene and is a potential target for chemoprevention of B-cell lymphomas.

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Citations

Feb 1, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stephen NesnowTanya Moore
Jun 1, 2012·The American Journal of Clinical Nutrition·Ashley J VargasPatricia A Thompson
Jun 6, 2013·Molecular Carcinogenesis·Edwin A PazEugene W Gerner
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Jan 12, 2020·Communications Biology·Musalula SinkalaDarren Patrick Martin
Oct 16, 2020·Nutrition and Cancer·Shaochen ShenHongwei Huang

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