PMID: 20103728DOI: 10.1158/1940-6207.capr-09-0252Jan 28, 2010Paper
Cancer chemoprevention locks onto a new polyamine metabolic target.
Cancer Prevention Research
E W Gerner
Abstract
Ornithine decarboxylase has a relatively long history as a target for cancer chemoprevention and chemotherapy. Plym Forshell et al. report new evidence (beginning on p. 140 in this issue of the journal) indicating that spermidine synthase, a fellow enzyme of ornithine decarboxylase in polyamine metabolism, is transactivated in part by the MYC gene and is a potential target for chemoprevention of B-cell lymphomas.
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