Chromosomal instability (CIN)-which is a high rate of loss or gain of whole or parts of chromosomes-is a characteristic of most human cancers and a cause of tumour aneuploidy and intra-tumour heterogeneity. CIN is associated with poor patient outcome and drug resistance, which could be mediated by evolutionary adaptation fostered by intra-tumour heterogeneity. In this review, we discuss the clinical consequences of CIN and the challenges inherent to its measurement in tumour specimens. The relationship between CIN and prognosis supports assessment of CIN status in the clinical setting and suggests that stratifying tumours according to levels of CIN could facilitate clinical risk assessment.
Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy
Chromosomal instability detected by fluorescence in situ hybridization in Japanese breast cancer patients
Identification of genes periodically expressed in the human cell cycle and their expression in tumors
Overexpression of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 in gastric cancer--association with tumour cell proliferation
Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint
Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity
Chromosomal and genetic imbalances in synovial sarcoma detected by conventional and microarray comparative genomic hybridization
A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer
Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer
Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients
The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers
Chromosomal instability correlates with poor outcome in patients with myelodysplastic syndromes irrespectively of the cytogenetic risk group
Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity
Familial clustering and DRD4 effects on electroencephalogram measures in multiplex families with attention deficit/hyperactivity disorder
Prognostic utility of chromosomal instability detected by fluorescence in situ hybridization in fine-needle aspirates from oral squamous cell carcinomas
The relationship between the presence of chromosomal instability and prognosis of squamous cell carcinoma of the lung: fluorescence in situ hybridization analysis of paraffin-embedded tissue from 47 Korean patients
Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes
How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine
A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables
Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy
Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites
Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer
Chromosomal heterogeneity and instability characterize pediatric medulloblastoma cell lines and affect neoplastic phenotype
Decreased expression and prognostic role of mitogen-activated protein kinase phosphatase 4 in hepatocellular carcinoma
Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery
The degree of segmental aneuploidy measured by total copy number abnormalities predicts survival and recurrence in superficial gastroesophageal adenocarcinoma
Chromosomal instability, aneuploidy and routine high-resolution DNA content analysis in oral cancer risk evaluation
Expression of regulators of mitotic fidelity are associated with intercellular heterogeneity and chromosomal instability in primary breast cancer
A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis
Centrosome amplification, chromosomal instability and cancer: mechanistic, clinical and therapeutic issues
Karyotypically distinct U251, U373, and SNB19 glioma cell lines are of the same origin but have different drug treatment sensitivities
Acquisition of paclitaxel resistance is associated with a more aggressive and invasive phenotype in prostate cancer
Correlation of morphological markers of chromosomal instability in fine needle aspiration cytology with grade of breast cancer
A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation
Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells
Systematic evaluation of the prognostic impact and intratumour heterogeneity of clear cell renal cell carcinoma biomarkers
A microRNA biomarker of hepatocellular carcinoma recurrence following liver transplantation accounting for within-patient heterogeneity
Genomic Copy Number Signatures Uncovered a Genetically Distinct Group from Adenocarcinoma and Squamous Cell Carcinoma in Non-Small Cell Lung Cancer
Modulation of cisplatin sensitivity in human ovarian carcinoma A2780 and SKOV3 cell lines by sulforaphane.
Extreme chromosomal instability forecasts improved outcome in ER-negative breast cancer: a prospective validation cohort study from the TACT trial
High level of chromosomal instability in circulating tumor cells of ROS1-rearranged non-small-cell lung cancer
Cancers of unknown primary origin (CUP) are characterized by chromosomal instability (CIN) compared to metastasis of know origin
Quantitative assessment of chromosome instability induced through chemical disruption of mitotic progression
Obstacles to precision oncology: confronting current factors affecting the successful introduction of biomarkers to the clinic
Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes
Transcriptional consequence and impaired gametogenesis with high-grade aneuploidy in Arabidopsis thaliana
Investigating cellular network heterogeneity and modularity in cancer: a network entropy and unbalanced motif approach
Tumor suppressor protein DAB2IP participates in chromosomal stability maintenance through activating spindle assembly checkpoint and stabilizing kinetochore-microtubule attachments
Tumour response in metastatic renal cell carcinoma treated with tyrosine kinase inhibitors - assessment of intra-tumour heterogeneity
Detection of Circulating Tumor Cells Using Negative Enrichment Immunofluorescence and an In Situ Hybridization System in Pancreatic Cancer
Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability
Extreme chromosome 17 copy number instability is a prognostic factor in patients with gastroesophageal adenocarcinoma: A retrospective cohort study
Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation
Not Everyone Fits the Mold: Intratumor and Intertumor Heterogeneity and Innovative Cancer Drug Design and Development
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERα)-positive mammary adenocarcinomas
Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid Neoplasia
Isolation and characterization of spontaneously immortalized B-lymphocyte lines from HIV-infected patients with and without non-Hodgkin's Lymphoma
DNA damage response proteins regulating mitotic cell division: double agents preserving genome stability
Prognostic value of mitotic checkpoint protein BUB3, cyclin B1, and pituitary tumor-transforming 1 expression in prostate cancer.
Heterogeneous Mechanisms of Secondary Resistance and Clonal Selection in Sarcoma during Treatment with Nutlin
Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival
Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines
TRIP13 impairs mitotic checkpoint surveillance and is associated with poor prognosis in multiple myeloma
The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression.
Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll
Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer
A microsatellite based multiplex PCR method for the detection of chromosomal instability in gastric cancer
Geraniin selectively promotes cytostasis and apoptosis in human colorectal cancer cells by inducing catastrophic chromosomal instability
Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential
Automatic Detection Method for Cancer Cell Nucleus Image Based on Deep-Learning Analysis and Color Layer Signature Analysis Algorithm.
Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.
Citron kinase (CIT-K) promotes aggressiveness and tumorigenesis of breast cancer cells in vitro and in vivo: preliminary study of the underlying mechanism
The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity
Telomere and Centromere Staining Followed by M-FISH Improves Diagnosis of Chromosomal Instability and Its Clinical Utility.
SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment
Clinical Implications of Chromosomal Instability (CIN) and Kinetochore Abnormalities in Breast Cancers
Recurrent Gastrointestinal Near-Tetraploid Diffuse Large B-Cell Lymphoma Causing Intussusception and Ileal Ulceration
Genomic Instability and TP53 Genomic Alterations Associate With Poor Antiproliferative Response and Intrinsic Resistance to Aromatase Inhibitor Treatment.
Distinct co-acquired alterations and genomic evolution during TKI treatment in non-small-cell lung cancer patients with or without acquired T790M mutation
High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation
Rapidly progressive metastatic adenocarcinoma of unknown primary 2 months following deceased donor renal transplantation-Donor- or recipient-derived?
Origins and Consequences of Chromosomal Instability: From Cellular Adaptation to Genome Chaos-Mediated System Survival.
The Landscape of Chromosome Instability in Breast Cancers and Associations with the Tumor Mutation Burden: An Analysis of Data from TCGA
Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution
FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A
Morphology-Predicted Large-Scale Transition Number in Circulating Tumor Cells Identifies a Chromosomal Instability Biomarker Associated with Poor Outcome in Castration-Resistant Prostate Cancer.
Chromosomal instability, DNA index, dysplasia, and subsite in oral premalignancy as intermediate endpoints of risk of cancer
Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer
Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715
Human artificial chromosome (HAC) for measuring chromosome instability (CIN) and identification of genes required for proper chromosome transmission.
Tumor Evolution and Therapeutic Choice Seen through a Prism of Circulating Tumor Cell Genomic Instability.
The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation
Molecular Signatures of Chromosomal Instability Correlate With Copy Number Variation Patterns and Patient Outcome in IDH-Mutant and IDH-Wildtype Astrocytomas.
Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis.
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer.
A quantitative and semiautomated method for determining misaligned and lagging chromosomes during mitosis.
Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A
The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells.
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