Cancer detection rate of prebiopsy MRI with subsequent systematic and targeted biopsy are superior to non-targeting systematic biopsy without MRI in biopsy naïve patients: a retrospective cohort study

BMC Urology
Satoshi WashinoTatsuo Morita

Abstract

To determine whether prebiopsy multiparametric magnetic resonance imaging (mpMRI) with subsequent systematic plus targeted biopsies for suspicious lesions improve prostate cancer detection compared with standard non-targeting systematic biopsies without mpMRI in biopsy-naïve patients. Patients who underwent their first prostate biopsy due to suspicion of prostate cancer were analyzed retrospectively to compare the biopsy outcomes between patients who received prebiopsy mpMRI (215 patients) and those who did not (281 patients). mpMRI was performed to determine pre-biopsy likelihood of the presence of prostate cancer using a three-point scale (1 = low level of suspicion, 2 = equivocal, and 3 = high level of suspicion). Systematic biopsies were performed in both groups. Targeted biopsies were added for a high level of suspicious lesions on mpMRI. All biopsies were performed by transperineal biopsy technique. After biopsy, Prostate Imaging Reporting and Data System ver. 2 (PIRADS-2) scoring was performed to describe the mpMRI findings and predictive value of PIRADS-2 was evaluated. The detection rate of total and clinically significant prostate cancer was significantly higher in patients who received prebiopsy mpMRI than in those w...Continue Reading

References

Sep 17, 2008·Magma·Yousef MazaheriHedvig Hricak
Sep 3, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Tomoaki MiyagawaTsuyoshi Mitake
Feb 11, 2012·European Radiology·Jelle O BarentszUNKNOWN European Society of Urogenital Radiology
Mar 20, 2012·European Urology·Melissa M CenterFreddie Bray
Sep 18, 2012·The Journal of Urology·Nicolas Barry DelongchampsFrançois Cornud
Oct 24, 2012·The Journal of Urology·Misop HanDan Stoianovici
Apr 5, 2013·BJU International·James L SymonsPhillip D Stricker
Apr 10, 2013·Current Urology Reports·Christiaan G OverduinJelle O Barentsz
Jan 24, 2014·AJR. American Journal of Roentgenology·Maarten de RooijMaroeska M Rovers
Dec 30, 2014·AJR. American Journal of Roentgenology·Derek W CoolAaron Fenster
Oct 3, 2015·European Urology·Jeffrey C WeinrebSadna Verma

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

SPSS
GraphPad
PIRADS
GraphPad Prism

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