Cancer dissemination--lessons from leukocytes

Developmental Cell
Chris D Madsen, Erik Sahai

Abstract

Cancer cells can move through tissues in a variety of different ways. In some cases, an epithelial-to-mesenchymal transition enables cancer cells to acquire fibroblast-like migratory properties. However, it is also becoming apparent that some cancer cells move in an amoeboid way similar to leukocytes. This theme will be the focus of the review, where we will discuss the similarities and differences between the mechanisms used by cancer cells and leukocytes to cross parenchymal basement membranes, move through interstitial tissue, and enter and exit the vasculature. Further, we propose that the ability to switch between different migratory mechanisms is critical for cells to relocate from one tissue to another.

References

Jan 1, 1984·Cancer Metastasis Reviews·G J Gasic
Dec 1, 1995·Experimental Cell Research·D Zicha, G A Dunn
Dec 31, 1997·The Journal of Experimental Medicine·A A PriceA Ager
Apr 16, 1998·International Journal of Cancer. Journal International Du Cancer·J KlominekD Hauzenberger
Apr 20, 1999·Nature Biotechnology·R WeisslederA Bogdanov
May 26, 1999·American Journal of Respiratory Cell and Molecular Biology·T BetsuyakuR M Senior
Feb 24, 2000·The Journal of Pathology·F W OrrD M Nance
Oct 26, 2000·Trends in Cell Biology·P RickertG Servant
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M J BrownS Shaw
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H GeminderA Ben-Baruch
Nov 8, 2001·Journal of the National Cancer Institute·H E WileyS T Hwang
Jan 29, 2002·Nature Immunology·Michel Aurrand-LionsBeat A Imhof
Mar 14, 2002·The American Journal of Pathology·Shunichi MorikawaDonald M McDonald
Apr 16, 2002·The International Journal of Biochemistry & Cell Biology·Gareth E JonesAdrian Thrasher
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gudrun RatzingerNikolaus Romani
May 7, 2002·Nature Cell Biology·Erik Sahai, Christopher J Marshall
May 8, 2002·Nature Reviews. Molecular Cell Biology·Margaret C FrameJohn A Wyke
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Sep 5, 2002·Nature Reviews. Cancer·Christopher Mark Overall, Carlos López-Otín
Jan 30, 2003·Clinical & Experimental Metastasis·Hironori KikkawaNaoto Oku
Mar 11, 2003·American Journal of Respiratory and Critical Care Medicine·Roderick J PhillipsRobert M Strieter
Mar 15, 2003·Nature Reviews. Cancer·Erik Sahai, Christopher J Marshall
Jun 5, 2003·Nature Reviews. Cancer·Raghu Kalluri
Jul 3, 2003·Trends in Cell Biology·Stefan Linder, Martin Aepfelbacher
Jul 8, 2003·The Journal of Pathology·Jean A Engbring, Hynda K Kleinman
Jul 11, 2003·Developmental Cell·David R Sherwood, Paul W Sternberg
Oct 1, 2003·Nature Genetics·Milagros BalbínCarlos López-Otín
Oct 28, 2003·The American Journal of Pathology·Peter BalukDonald M McDonald

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Citations

Nov 9, 2011·Nature Medicine·Kari Alitalo
Jun 2, 2011·Nature Reviews. Clinical Oncology·Katrien De BockPeter Carmeliet
Oct 18, 2012·Nature Reviews. Molecular Cell Biology·Peter FriedlKenneth M Yamada
Jan 11, 2012·Oncogene·L M R FerreiraJ E Dumont
Jun 21, 2013·Open Biology·Tea Vallenius
Oct 19, 2011·Pigment Cell & Melanoma Research·Rachel E Bell, Carmit Levy
May 24, 2012·Development·Jessica R K Seifert, Ruth Lehmann
Apr 26, 2013·Disease Models & Mechanisms·Miriam R Fein, Mikala Egeblad
Jun 3, 2014·BMC Cancer·Björn Ldm Brücher, Ijaz S Jamall
Mar 26, 2014·The Journal of Cell Biology·Elliott J HagedornDavid R Sherwood
Feb 5, 2014·The Journal of Cell Biology·Laura C KelleyDavid R Sherwood
Feb 28, 2014·Seminars in Immunopathology·Tim Lämmermann, Ronald N Germain
Jun 4, 2014·The Journal of Cell Biology·Brian T BeatyJohn Condeelis
Sep 5, 2012·The Journal of Cell Biology·Stephanie WooDidier Y R Stainier
Nov 14, 2012·The Journal of Cell Biology·Nicolas ReymondAnne J Ridley
Jun 12, 2013·The Journal of Cell Biology·Elliott J HagedornDavid R Sherwood
Jun 5, 2015·International Journal of Cancer. Journal International Du Cancer·Takatsugu IshimotoPatrick Tan
Jul 23, 2014·The Journal of Cell Biology·Emanuela FrittoliGiorgio Scita
Jun 29, 2011·The Journal of Cell Biology·Hideki YamaguchiKiyoko Fukami
Jul 17, 2012·Trends in Molecular Medicine·Sébastien L FloorEric Raspe
Jun 5, 2012·European Journal of Cell Biology·Hideki Yamaguchi
Jun 19, 2012·European Journal of Cell Biology·Asier Jayo, Maddy Parsons
Oct 29, 2011·Free Radical Biology & Medicine·Begoña Díaz, Sara A Courtneidge
Dec 23, 2011·Cancer Science·Kazuhiro AokiMichiyuki Matsuda
Dec 4, 2012·Journal of Internal Medicine·L Moserle, O Casanovas
May 10, 2012·Cell Adhesion & Migration·Yoshiya HorimotoAkira Orimo
Apr 11, 2014·Cell Adhesion & Migration·Lauren L LohmerDavid R Sherwood
May 15, 2012·Cell Cycle·Robin L MacintoshKevin M Ryan
Jun 25, 2013·Cell Adhesion & Migration·Heather S Carr, Jeffrey A Frost
Apr 30, 2014·Worm·Meghan A MorrisseyDavid R Sherwood
Jun 3, 2011·Current Opinion in Cell Biology·Elliott J Hagedorn, David R Sherwood

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