Cancer evolution, mutations, and clonal selection in relapse neuroblastoma.

Cell and Tissue Research
Marc SchulteAlexander Schramm

Abstract

The notion of cancer as a complex evolutionary system has been validated by in-depth molecular analyses of tumor progression over the last years. While a complex interplay of cell-autonomous programs and cell-cell interactions determines proliferation and differentiation during normal development, intrinsic and acquired plasticity of cancer cells allow for evasion of growth factor limitations, apoptotic signals, or attacks from the immune system. Treatment-induced molecular selection processes have been described by a number of studies already, but understanding of those events facilitating metastatic spread, organ-specific homing, and resistance to anoikis is still in its early days. In principle, somatic events giving rise to cancer progression should be easier to follow in childhood tumors bearing fewer mutations and genomic aberrations than their counterparts in adulthood. We have previously reported on the genetic events accompanying relapsing neuroblastoma, a solid tumor of early childhood. Our results indicated significantly higher single nucleotide variants in relapse tumors, gave hints for branched tumor evolution upon treatment and clonal selection as deduced from shifts in allelic frequencies between primary and rela...Continue Reading

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Citations

Apr 7, 2018·Cell and Tissue Research·Katrin HuberArthur S Tischler
Oct 29, 2020·Journal of Experimental & Clinical Cancer Research : CR·Amparo López-CarrascoRosa Noguera
Jun 26, 2021·Computers in Biology and Medicine·Nazanin HosseinkhanMohammad E Khamseh
Jul 22, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nathalie S M LakJanine Stutterheim

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Methods Mentioned

BETA
single
biopsies
exome sequencing
transgenic

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