Dec 23, 2008

Cancer gene silencing without DNA hypermethylation

Epigenetics : Official Journal of the DNA Methylation Society
Qiang Yu

Abstract

Both DNA hypermethylation and Polycomb-mediated histone methylation induce gene silencing in cancer, but largely in two separate paths. Hence, different pharmacologic approaches are required to reactivate genes silenced by distinct epigenetic mechanisms.

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Mentioned in this Paper

Genes
Histone Methylation
DNA Methylation
Study of Epigenetics
Methylation
Chromatin Remodeling Factor
Malignant Neoplasms
Histone H7
DNA Hypermethylation
Polycomb

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