PMID: 3757415Sep 1, 1986Paper

Cancer genes: their clinical potential

Clinical Radiology
K Sikora

Abstract

The central problem in cancer therapy is the poor selectivity of current systemic agents against the common solid tumours. The demonstration that unique segments of DNA, constant in location and conserved in evolution, are involved in growth control opens new avenues for basic and clinical research. The functions of the products of these oncogenes need to be elucidated. Examples of growth control functions include homology to growth factors, surface receptors, protein kinases and cell cycle control proteins. From DNA sequence data peptides predicted to be exposed within intact molecules have been constructed and used to produce monoclonal antibodies to oncogene products. Such antibodies have demonstrated the intracellular localisation of oncogene products and their cell cycle regulatory role. A battery of antibodies against the different oncogene products can be used to aid diagnosis and prognosis. Immunohistology and other methods permit the geographical and quantitative analysis of oncoprotein function in normal and neoplastic tissues. New tumour marker systems have been uncovered. Furthermore, by purification and biochemical analysis the molecular basis for the action of these proteins can be elucidated. It is likely that by...Continue Reading

References

Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D H SpectorJ M Bishop
Feb 1, 1982·Cancer Genetics and Cytogenetics·P E Barker
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P P ChenD A Carson
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T Hunter, B M Sefton
Dec 1, 1984·Cancer Treatment Reviews·A U Buzdar, G R Blumenschein
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Aug 1, 1982·Cell·R A Weinberg
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B G NeelW S Hayward

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