Cancer genomics: the challenge of drug accessibility

Current Opinion in Oncology
Jeremy Lewin, Lillian L Siu

Abstract

Although significant strides have been made in genome sequencing technology, target-drug matching remains challenging. This article highlights the difficulties associated with patients accessing targeted drugs based on genomic information, and some proposed solutions. Although cancers are increasingly stratified according to molecular subgroups, challenges remain in improving patient outcome based on drug-target matching. Before a drug-target match is even proposed, significant expertise is required of the clinician to interpret genomic information. Once a potential match is made, barriers remain for patients to access treatment via clinical trials, as approved agents on-label or off-label, or through expanded access programs. Solutions to improve drug accessibility are actively being investigated. Several prospective trials using molecular characterization as an entry to access target-drug matching are underway. For those unable to access target-drug matching on trial, proposals for a facilitated access program and registry have been suggested. Although improvements have been made in the drug development and approval timelines, drug accessibility based on molecular characterization remains problematic. However, with the emerge...Continue Reading

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Citations

Feb 26, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Gabriel MakHendrik-Tobias Arkenau
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Software Mentioned

- SPY )
Imaging
OncoSeq
Mi
moLecular Analysis (

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