Cancer-immune interactions in ER-positive breast cancers: PI3K pathway alterations and tumor-infiltrating lymphocytes

Breast Cancer Research : BCR
Marcelo Sobral-LeiteMarleen Kok

Abstract

The presence of tumor-infiltrating lymphocytes (TILs) is correlated with good prognosis and outcome after (immuno)therapy in triple-negative and HER2-positive breast cancer. However, the role of TILs in luminal breast cancer is less clear. Emerging evidence has now demonstrated that genetic aberrations in malignant cells influence the immune landscape of tumors. Phosphatidylinositol 3-kinase (PI3K) is the most common altered pathway in ER-positive breast cancer. It is unknown whether changes in the PI3K pathway result in a different composition of the breast tumor microenvironment. Here we present the retrospective analysis of a prospective randomized trial in ER-positive breast cancer on the prognostic and predictive value of specific tumor-associated lymphocytes in the context of PI3K alterations. We included 563 ER-positive tumors from a multicenter trial for stage I to III postmenopausal breast cancer patients, who were randomized to tamoxifen or no adjuvant therapy. The amount of CD8-, CD4-, and FOXP3-positive cells was evaluated by immunohistochemistry and quantified by imaging-analysis software. We analyzed the associations between PIK3CA hotspot mutations, PTEN expression, phosphorylated proteins of the PI3K and MAPK pa...Continue Reading

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Citations

Jul 6, 2020·Breast Cancer Research and Treatment·C CriscitielloG Curigliano
Dec 28, 2019·Breast Cancer Research : BCR·Iris NederlofChristine Desmedt
Aug 28, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Valentina GuarneriPierfranco Conte
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Jan 28, 2021·Cells·Maria Vittoria DieciValentina Guarneri
Jan 9, 2021·Breast Cancer Research : BCR·Amy E McCart ReedSunil R Lakhani
Dec 31, 2020·International Journal of Molecular Sciences·Daniela MiricescuMaria Greabu
Apr 2, 2021·Frontiers in Oncology·Keying ZhangWeijun Qin
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Aug 25, 2021·The American Journal of Pathology·Sepideh MojtahedzadehSripad Ram

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Methods Mentioned

BETA
genotyping

Software Mentioned

MaxKappa
RStudio
R package :
Slidepath
Tissue Image Analysis

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