Cancer immune therapy for lymphoid malignancies: recent advances

Seminars in Immunopathology
Uffe KlausenMads Hald Andersen

Abstract

Immunotherapy has played an important part in improving the life of patients with lymphoproliferative diseases especially since the addition of rituximab to chemotherapy in the CD20-positive neoplasms in the 1990s. While this field of passive immunotherapy is continuously evolving, several breakthroughs will expand the treatment modalities to include more active immunotherapy. With the approval of immune checkpoint-blocking antibodies for Hodgkin lymphoma and bispecific antibodies for acute lymphoblastic leukemia (ALL), activation of endogenous T cells already plays a role in several lymphoid malignancies. With the approval of cellular therapies with CAR-T cells for ALL and diffuse large B cell lymphoma, the impact of the manipulation of immune responses is taken even further. Vaccines are cellular therapies in the opposite end of the spectrum in terms of side effects, and while the big breakthrough is still to come, the prospect of a very low-toxic immunotherapy which could be applicable also in premalignant states or in frail patients drives a considerable research activity in the area. In this review, we summarize the mechanisms of action and clinical data on trials in the lymphoid neoplasms with chimeric antigen receptor T ...Continue Reading

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Citations

Sep 23, 2018·Seminars in Immunopathology·Mads Hald Andersen
Feb 8, 2019·British Journal of Haematology·Monika L Metzger, Christine Mauz-Körholz
Mar 9, 2019·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Leonard D ShultzMichael A Brehm
Oct 23, 2019·Signal Transduction and Targeted Therapy·Dan LiWei Wang
Feb 25, 2019·Journal of Cancer Research and Clinical Oncology·Lin Yu, Jianhua Wang
Nov 2, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Adam D CohenMadhav V Dhodapkar
Feb 15, 2020·Pathology, Research and Practice·Zhu LinglingZhou Qinghua
Sep 20, 2020·Signal Transduction and Targeted Therapy·Dan LiWei Wang

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Methods Mentioned

BETA
transfection

Clinical Trials Mentioned

NCT02601313
NCT02658929
NCT03168438
NCT02665650
NCT03192202
NCT02684292
NCT03138499
NCT02036502
NCT02579863
NCT02576977

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