Cancer immunotherapy: A need for peripheral immunodynamic monitoring

American Journal of Reproductive Immunology : AJRI
Wenjun WangJianxing He

Abstract

Immunotherapy has become an important approach for treating different tumours which has shown significant efficacy in numerous clinical trials, especially those using new checkpoint inhibitors and adoptive cell therapy, which have rapidly become widespread after being approved. However, analysis of peripheral immune biomarkers before and after immunotherapy and their relationship to clinical responses and disease prognosis have rarely been performed in clinical trials. In this review, we examine dynamic changes in the immune system before and after therapy by analyzing recent clinical trials of immunotherapy in patients with cancer that focused on checkpoint inhibitors and adoptive cell therapy. Our aim was to identify circulating biomarkers which can specifically predict clinical response and prognosis, as well as toxicities of immunotherapy. Through this approach, we hope to advance our understanding of the mechanisms of immunotherapy with the goal of developing individualized treatment for cancer patients.

References

Nov 8, 2001·Trends in Immunology·M A CooperM A Caligiuri
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cor H J LamersEgbert Oosterwijk
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael H KershawPatrick Hwu
Jan 26, 2007·Nature Reviews. Cancer·Ignacio MeleroLieping Chen
Feb 15, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Julie R ParkMichael C Jensen
May 5, 2007·Cancer Immunology, Immunotherapy : CII·Cor H J LamersJan Willem Gratama
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Aug 13, 2010·Cancer Biotherapy & Radiopharmaceuticals·Xiaosan SuTao Guo
Oct 23, 2010·Science·Jennifer Couzin-Frankel
Aug 17, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria R ParkhurstSteven A Rosenberg
Sep 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Evan J Lipson, Charles G Drake
Dec 24, 2011·Nature·Ira MellmanGlenn Dranoff
Mar 27, 2012·Expert Opinion on Biological Therapy·Sharmilan ThanendrarajanIngo Schmidt-Wolf
May 4, 2012·Science Translational Medicine·John SchollerCarl H June
Jul 14, 2012·Journal of Translational Medicine·Wenshi WangJeffrey S Weber
Feb 21, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Cor Hj LamersJan W Gratama
Mar 5, 2013·Journal of Translational Medicine·Paolo A AsciertoBernard A Fox
Mar 27, 2013·The New England Journal of Medicine·Stephan A GruppCarl H June
Jan 3, 2014·Clinical & Developmental Immunology·Yajing ZhangWei-Dong Han
Mar 5, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Suzanne L TopalianF Stephen Hodi
Jul 8, 2014·The Medical Journal of Australia·Marliese AlexanderDamien Kee
Jul 9, 2014·Nature Biotechnology·Laura DeFrancesco
Dec 3, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J MotzerHans J Hammers
Dec 20, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Geoffrey T GibneyJeffrey S Weber
Mar 18, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jinying ZhangYongqian Shu
Apr 22, 2015·The New England Journal of Medicine·Edward B GaronUNKNOWN KEYNOTE-001 Investigators
Apr 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S WeberMary L Disis
Apr 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Emanuela RomanoDaniel E Speiser
Jun 13, 2015·Immunotherapy·Yarne KlaverCor H J Lamers

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