Cancer immunotherapy: moving beyond current vaccines

Nature Medicine
Steven A RosenbergNicholas P Restifo

Abstract

Great progress has been made in the field of tumor immunology in the past decade, but optimism about the clinical application of currently available cancer vaccine approaches is based more on surrogate endpoints than on clinical tumor regression. In our cancer vaccine trials of 440 patients, the objective response rate was low (2.6%), and comparable to the results obtained by others. We consider here results in cancer vaccine trials and highlight alternate strategies that mediate cancer regression in preclinical and clinical models.

Associated Clinical Trials

Jun 30, 2008·Steven Rosenberg, M.D., Steven Rosenberg, M.D.

References

Jan 1, 1981·Cancer·A B MillerA Winkler
Mar 24, 1999·Journal of the National Cancer Institute·K JamesP Therasse
Mar 27, 1999·Journal of Immunotherapy·S N KhleifJ Schlom
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J L MarshallJ Schlom
Oct 26, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W J van DrielJ B Trimbos
Sep 27, 2000·International Journal of Cancer. Journal International Du Cancer·S JanetzkiP K Srivastava
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·E JägerA Knuth
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·L FongE G Engleman
Nov 28, 2001·Immunological Reviews·E M ShevachA M Thornton
Oct 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Filiberto BelliGiorgio Parmiani
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A StiftM Gnant
Jan 14, 2003·Annual Review of Immunology·Kiyoshi TakedaShizuo Akira
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amy C PetersonThomas F Gajewski
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antoni RibasJames S Economou
Jun 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Giao Q PhanSteven A Rosenberg
Aug 20, 2003·The Journal of Experimental Medicine·Willem W OverwijkNicholas P Restifo
Nov 6, 2003·Cancer Immunology, Immunotherapy : CII·Peter HerseyMargaret Lett
Jan 9, 2004·Advances in Immunology·Shohei HoriShimon Sakaguchi

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Citations

May 30, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Shin-ichiro FujiiKanako Shimizu
Aug 4, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Akshata Udyavar, Terrence L Geiger
Aug 10, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Marek Jakóbisiak, Jakub Gołab
Mar 11, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ken-ichi Hanada, James C Yang
Sep 6, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Fabrizio VianelloMark C Poznansky
Jul 10, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Thomas Sayers
Mar 31, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Cristina MastiniRoberto Chiarle
Sep 10, 2005·Cancer Immunology, Immunotherapy : CII·Dean JohnstonJean-Claude Bystryn
May 9, 2006·Cancer Immunology, Immunotherapy : CII·Thomas B TomasiA Nazmul H Khan
Nov 11, 2006·Cancer Immunology, Immunotherapy : CII·Danièle GodelaineAline Van Pel
Dec 2, 2006·Cancer Immunology, Immunotherapy : CII·Dean JohnstonJean-Claude Bystryn
May 16, 2007·Cancer Immunology, Immunotherapy : CII·Sandra TuyaertsAude Bonehill
May 25, 2007·Cancer Immunology, Immunotherapy : CII·Justin T JordanAmy B Heimberger
Sep 6, 2007·Cancer Immunology, Immunotherapy : CII·Tsukasa NabekuraMasafumi Onodera
Feb 13, 2008·Cancer Immunology, Immunotherapy : CII·Stephanie S Tseng-RogenskiMartin G Sanda
Apr 4, 2008·Cancer Immunology, Immunotherapy : CII·Benjamin B WilliamsRobert G Ramsay
May 20, 2008·Cancer Immunology, Immunotherapy : CII·Rupal RamakrishnanDmitry I Gabrilovich
Jul 17, 2008·Cancer Immunology, Immunotherapy : CII·Jian-Qing GaoShinsaku Nakagawa
Sep 23, 2008·Cancer Immunology, Immunotherapy : CII·Jonathan BegleyAntoni Ribas
Nov 11, 2008·Cancer Immunology, Immunotherapy : CII·Manuela IeroLicia Rivoltini
Nov 13, 2008·Cancer Immunology, Immunotherapy : CII·Ling-Yuan KongAmy B Heimberger
Feb 3, 2009·Cancer Immunology, Immunotherapy : CII·Tsukasa Seya, Misako Matsumoto
Mar 5, 2009·Cancer Immunology, Immunotherapy : CII·Cedrik Michael BrittenUNKNOWN HLA-peptide Multimer Proficiency Panel of the CVC-CRI Immune Assay Working Group
Mar 7, 2009·Cancer Immunology, Immunotherapy : CII·Andrea WorschechAladar A Szalay
Nov 27, 2009·Cancer Immunology, Immunotherapy : CII·Miki TonguMamoru Harada
Jan 1, 2010·Cancer Immunology, Immunotherapy : CII·Adam DangoorRobert Hawkins
Oct 27, 2010·Cancer Immunology, Immunotherapy : CII·Rupal Ramakrishnan, Dmitry I Gabrilovich
Nov 23, 2010·Cancer Immunology, Immunotherapy : CII·Huanfa YiXiang-Yang Wang
Mar 15, 2011·Cancer Immunology, Immunotherapy : CII·Karen S AndersonEllis L Reinherz
Jun 1, 2011·Cancer Immunology, Immunotherapy : CII·Isabel PoschkeRolf Kiessling
May 10, 2011·Cancer Immunology, Immunotherapy : CII·Cristina GarridoFederico Garrido

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