Cancer immunotherapy using tumor cryoablation

Immunotherapy
Abhinav Sidana

Abstract

Cryoablation is increasingly being used as a primary treatment for localized cancers and as a salvage therapy for metastatic cancers. Anecdotal clinical reports and animal experiments have confirmed an induction of systemic antitumor immune response by tumor cryoablation. To capitalize on the stimulatory effects of cryoablation for cancer immunotherapy, this response must be intensified using other immunomodulatory agents. This article reviews the preclinical and clinical evidence and discusses the mechanism of the antitumor immune response generated by cryoablation. The rationale and evidence behind several immunotherapy approaches that can be combined with cryoablation to devise a cryoimmunotherapeutic strategy with a potential to impact the progression of metastatic disease are described.

References

Apr 1, 1986·The Journal of Dermatologic Surgery and Oncology·E G Kuflik
May 1, 1973·Urology·E O GurselR J Veenema
Apr 1, 1968·Archives of Surgery·F T MooreW G Pace
Dec 1, 1974·The Journal of Surgical Research·D H BagleyR M Beazley
Dec 1, 1972·Cryobiology·C E Blackwood, I S Cooper
Aug 19, 1972·British Medical Journal·R J Ablin
Oct 13, 1965·Annals of the New York Academy of Sciences·M J GonderV Smith
Jul 1, 1970·Clinical Radiology·W A SoanesR J Ablin
Jul 1, 1967·Cryobiology·J BlackwoodW G Pace
Jan 1, 1966·Cryobiology·S A Zacarian, M I Adham
Sep 1, 1967·The British Journal of Surgery·J Fraser, W Gill
Jan 1, 1981·The Prostate·D M LubaroffT Feldbush
Sep 1, 1984·The American Journal of Physiology·P Mazur
Oct 1, 1984·Journal of Surgical Oncology·J A Zonnevylle, A Zwaveling
Jan 1, 1982·Progress in Clinical and Biological Research·S Tanaka
Jan 1, 1981·Journal of Surgical Oncology·W F SindelarD H Bagley
Oct 1, 1996·Seminars in Immunology·E J Fuchs, P Matzinger
Feb 1, 1997·Annals of Surgery·N N Korpan
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·E D KwonJ P Allison
Sep 12, 1998·The Journal of Surgical Research·P J AllenY Fong
Mar 29, 2002·European Journal of Immunology·Todd N EagarStephen D Miller
Sep 7, 2002·Urology·Nathan E Hoffmann, John C Bischof
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoshiko IwaiNagahiro Minato
Jan 31, 2003·European Journal of Immunology·Denise GolgherAwen Gallimore
Sep 17, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ralph M Steinman
Nov 12, 2003·The Journal of Urology·David M NanusNeil H Bander
Jan 7, 2004·Nature Reviews. Cancer·Glenn Dranoff
Jan 5, 2005·The Lancet Oncology·René VethJacky de Rooy
Mar 17, 2005·Breast Cancer Research and Treatment·Michael S SabelAlfred E Chang
Mar 24, 2005·Journal of Surgical Oncology·Pat W Whitworth, John C Rewcastle
Jul 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Arthur MachlenkinLea Eisenbach
Dec 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Masaru UdagawaYutaka Kawakami
Jan 27, 2007·Journal of the American College of Surgeons·Nikolai N Korpan

❮ Previous
Next ❯

Citations

Jan 23, 2014·Immunology Letters·Agrimaldo Martins FilhoRosekeila Simões Nomelini
Apr 1, 2014·Advanced Drug Delivery Reviews·Johan Unga, Mitsuru Hashida
Jan 28, 2017·Pancreas·Wenlong ZhangLizhi Niu
Jun 1, 2017·Nature Reviews. Urology·Takahiro KimuraHirotsugu Uemura
Oct 14, 2017·Immunological Reviews·Yuting MaHeng Yang
Apr 20, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Mi ZhangHuasong Feng
Nov 27, 2019·Current Oncology Reports·Dimitrios K FilippiadisAlexis Kelekis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.