Cancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease

Journal of Crohn's & Colitis
L MartheyF Carbonnel

Abstract

Therapeutic monoclonal anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) antibodies are associated with immune-mediated enterocolitis. The aim of this study was to provide a detailed description of this entity. We included patients with endoscopic signs of inflammation after anti-CTLA-4 infusions for cancer treatment. Other causes of enterocolitis were excluded. Clinical, biological and endoscopic data were recorded. A single pathologist reviewed endoscopic biopsies and colectomy specimens from 27 patients. Patients with and without enterocolitis after ipilimumab-treated melanoma were compared, to identify clinical factors associated with enterocolitis. Thirty-nine patients with anti-CTLA-4 enterocolitis were included (ipilimumab n = 37; tremelimumab n = 2). The most frequent symptom was diarrhoea. Ten patients had extra-intestinal manifestations. Most colonoscopies showed ulcerations involving the rectum and sigmoid, 66% of patients had extensive colitis, 55% had patchy distribution and 20% had ileal inflammation. Endoscopic colonic biopsies showed acute colitis in most patients, while half of the patients had chronic duodenitis. Thirty-five patients received steroids that led to complete clinical remission in 13 patie...Continue Reading

References

Aug 1, 1995·The Journal of Experimental Medicine·M F Krummel, J P Allison
Nov 4, 1993·Nature·M AzumaC Somoza
Apr 2, 1999·Immunology and Cell Biology·K D McCoy, G Le Gros
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·F Stephen HodiGlenn Dranoff
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kimberly E BeckJames C Yang
Aug 15, 2006·Immunological Reviews·David M Sansom, Lucy S K Walker
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·F Stephen HodiGlenn Dranoff
Jan 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John M KirkwoodCecile A Bulanhagui
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Nov 16, 2010·Seminars in Oncology·Anna Maria Di GiacomoMichele Maio
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok
Dec 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ahmad A TarhiniJohn M Kirkwood
Mar 7, 2012·Annals of Internal Medicine·Ashwin N AnanthakrishnanAndrew T Chan
May 2, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas J LynchMartin Reck
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S WeberAxel Hauschild
Jul 4, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chun Jing WangLucy S K Walker
Jan 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antoni RibasAxel Hauschild
Jul 31, 2013·The Journal of Experimental Medicine·Yannick BulliardJennifer L Brogdon
Jun 8, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M AgliettaF Leone
Feb 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michele MaioJedd D Wolchok
Apr 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Emanuela RomanoDaniel E Speiser
Jun 17, 2015·Alimentary Pharmacology & Therapeutics·A GuptaS Khanna

❮ Previous
Next ❯

Citations

Sep 25, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shunichi YanaiTakayuki Matsumoto
Dec 3, 2016·The Journal of Allergy and Clinical Immunology·Alexander A NavariniMike Recher
Jan 18, 2017·Seminars in Immunopathology·Franck CarbonnelCaroline Robert
May 27, 2017·Cancer Investigation·Giorgos BamiasHelen Gogas
Apr 4, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ChaputF Carbonnel
Jan 27, 2017·Current Gastroenterology Reports·Peyton Cramer, Robert S Bresalier
Jun 13, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shunichi YanaiTakayuki Matsumoto
Mar 8, 2018·Nature Reviews. Gastroenterology & Hepatology·Mark A SamaanPeter M Irving
Feb 15, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R BrahmerUNKNOWN National Comprehensive Cancer Network
Mar 2, 2018·Human Vaccines & Immunotherapeutics·Audrey Humphries, Adil Daud
Nov 23, 2017·Journal for Immunotherapy of Cancer·I PuzanovUNKNOWN Society for Immunotherapy of Cancer Toxicity Management Working Group
Jan 24, 2018·World Journal of Gastroenterology : WJG·Anne BozonGuillaume Pineton de Chambrun
Jul 12, 2018·British Journal of Hospital Medicine·Benjamin A Pickwell-SmithRuth E Board
Jul 18, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P J LarkinUNKNOWN ESMO Guidelines Committee
Aug 2, 2018·Current Oncology Reports·David J Palmieri, Matteo S Carlino
Dec 24, 2018·Expert Review of Anticancer Therapy·Barouyr BaroudjianUNKNOWN PATIO group
Oct 19, 2017·ACG Case Reports Journal·Madeline BerthaStephen Hanauer
Aug 23, 2018·Gut·Emilie SoularueFranck Carbonnel
Dec 7, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jay A FishmanMarcela V Maus
Apr 30, 2019·Alimentary Pharmacology & Therapeutics·Andrew P WrightRyan W Stidham
Jun 1, 2017·American Society of Clinical Oncology Educational Book·Melinda YushakRagini Kudchadkar
Nov 20, 2019·Current Treatment Options in Gastroenterology·Tara Menon, Anita Afzali
Nov 9, 2019·Journal for Immunotherapy of Cancer·Michael S HughesMichael Dougan
Jan 11, 2020·The American Journal of Gastroenterology·Emanuelle Bellaguarda, Stephen Hanauer
Nov 7, 2019·Histopathology·Melanie JohncillaAmitabh Srivastava
Jun 26, 2020·Journal for Immunotherapy of Cancer·Yousef R BadranMichael Dougan
Oct 15, 2019·Current Opinion in Gastroenterology·Hamzah Abu-SbeihYinghong Wang
Feb 7, 2020·Journal of Immunotherapy·Karoline HorisbergerMatthias Turina
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Shilpa GroverRamona M Lim
Dec 1, 2018·Mucosal Immunology·Maria E JoosseJanneke N Samsom
Jan 16, 2019·Therapeutic Advances in Gastroenterology·Shaji Sebastian, Steven Neilaj
Jun 23, 2019·Cancers·Debora BasileFabio Puglisi
Apr 8, 2020·BMJ : British Medical Journal·Karmela K Chan, Anne R Bass
Aug 29, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Michael DouganBernardo L Rapoport
Jul 12, 2019·Frontiers in Oncology·Caoilfhionn ConnollyJarushka Naidoo

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